The roles and regulation of the KLF5 transcription factor in cancers

Y Luo, C Chen - Cancer science, 2021 - Wiley Online Library
Krüppel‐like factor 5 (KLF5) is a member of the KLF family. Recent studies have suggested
that KLF5 regulates the expression of a large number of new target genes and participates …

The complexity of prostate cancer: genomic alterations and heterogeneity

LK Boyd, X Mao, YJ Lu - Nature reviews urology, 2012 - nature.com
Although prostate cancer is the most common malignancy to affect men in the Western
world, the molecular mechanisms underlying its development and progression remain …

Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases

JT Dong, C Chen - Cellular and molecular life sciences, 2009 - Springer
Abstract KLF5 (Kruppel-like factor 5) is a basic transcription factor binding to GC boxes at a
number of gene promoters and regulating their transcription. KLF5 is expressed during …

Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation

AM Ghaleb, MO Nandan, S Chanchevalap, WB Dalton… - Cell research, 2005 - nature.com
Krüppel-like factors (KLFs) are evolutionarily conserved zinc finger-containing transcription
factors with diverse regulatory functions in cell growth, proliferation, differentiation, and …

The diverse functions of Krüppel‐like factors 4 and 5 in epithelial biology and pathobiology

BB McConnell, AM Ghaleb, MO Nandan, VW Yang - Bioessays, 2007 - Wiley Online Library
The Krüppel-like factors (KLFs) comprise a family of evolutionarily conserved zinc finger
transcription factors that regulate numerous biological processes including proliferation …

Targeting autophagy in prostate cancer: preclinical and clinical evidence for therapeutic response

M Ashrafizadeh, MDA Paskeh, S Mirzaei… - Journal of Experimental …, 2022 - Springer
Prostate cancer is a leading cause of death worldwide and new estimates revealed prostate
cancer as the leading cause of death in men in 2021. Therefore, new strategies are pertinent …

Prevalent mutations in prostate cancer

JT Dong - Journal of cellular biochemistry, 2006 - Wiley Online Library
Quantitative and structural genetic alterations cause the development and progression of
prostate cancer. A number of genes have been implicated in prostate cancer by genetic …

[HTML][HTML] Evasion of anti-growth signaling: A key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds

ARMR Amin, PA Karpowicz, TE Carey, J Arbiser… - Seminars in cancer …, 2015 - Elsevier
The evasion of anti-growth signaling is an important characteristic of cancer cells. In order to
continue to proliferate, cancer cells must somehow uncouple themselves from the many …

Overexpression of the cell adhesion molecules DDR1, Claudin 3, and Ep-CAM in metaplastic ovarian epithelium and ovarian cancer

VA Heinzelmann-Schwarz, M Gardiner-Garden… - Clinical Cancer …, 2004 - AACR
Purpose: A better understanding of the molecular pathways underlying the development of
epithelial ovarian cancer (EOC) is critical to identify ovarian tumor markers for use in …

KLF4 and KLF5 regulate proliferation, apoptosis and invasion in esophageal cancer cells

Y Yang, BG Goldstein, HH Chao, J Katz - Cancer biology & therapy, 2005 - Taylor & Francis
KLF4 and KLF5, members of the KLF family of transcription factors, play key roles in
proliferation, differentiation, and carcinogenesis in a number of gastrointestinal tissues …