Proteins rarely carry out their cellular functions in isolation. Instead, eukaryotic proteins
engage in about six interactions with other proteins on average. The aggregated protein …

In recent years control theory has been applied to biological systems with the aim of
identifying the minimum set of molecular interactions that can drive the network to a required …

Deciding the size of a minimum dominating set is a classic NP-complete problem. It has
found increasing utility as the basis for classifying vertices in networks derived from protein …

The brain controls various cognitive functions in a robust and efficient way. What is the
control architecture of brain networks that enables such robust and optimal control? Is this …

Isoform switching is a recently characterized hallmark of cancer, and often translates to the
loss or gain of domains mediating protein interactions and thus, the re-wiring of the …

Identification of master regulatory genes is one of the primary challenges in systems biology.
The minimum dominating set problem is a powerful paradigm in analyzing such complex …

Gene dependency networks often undergo changes in response to different conditions.
Understanding how these networks change across two conditions is an important task in …

The minimum dominating set (MDSet) comprises the smallest number of graph nodes,
where other graph nodes are connected with at least one MDSet node. The MDSet has …

Network science has recently integrated key concepts from control theory and has applied
them to the analysis of the controllability of complex networks. One of the proposed …

Human diseases are not only associated to mutations in protein-coding genes. Contrary to
what was thought decades ago, the human genome is largely transcribed which generates a …