Metabolic engineering: methodologies and applications

MJ Volk, VG Tran, SI Tan, S Mishra, Z Fatma… - Chemical …, 2022 - ACS Publications
Metabolic engineering aims to improve the production of economically valuable molecules
through the genetic manipulation of microbial metabolism. While the discipline is a little over …

Sustainable production and degradation of plastics using microbes

SY Choi, Y Lee, HE Yu, IJ Cho, M Kang, SY Lee - Nature Microbiology, 2023 - nature.com
Plastics are indispensable in everyday life and industry, but the environmental impact of
plastic waste on ecosystems and human health is a huge concern. Microbial biotechnology …

A comprehensive metabolic map for production of bio-based chemicals

SY Lee, HU Kim, TU Chae, JS Cho, JW Kim, JH Shin… - Nature …, 2019 - nature.com
Production of industrial chemicals using renewable biomass feedstock is becoming
increasingly important to address limited fossil resources, climate change and other …

Escherichia coli as a host for metabolic engineering

S Pontrelli, TY Chiu, EI Lan, FYH Chen, P Chang… - Metabolic …, 2018 - Elsevier
Over the past century, Escherichia coli has become one of the best studied organisms on
earth. Features such as genetic tractability, favorable growth conditions, well characterized …

Recent advances in systems metabolic engineering tools and strategies

TU Chae, SY Choi, JW Kim, YS Ko, SY Lee - Current opinion in …, 2017 - Elsevier
Highlights•Microbial cell factories are becoming important in sustainable chemical
production.•Systems metabolic engineering allows efficient microbial cell factory …

Microbial polyhydroxyalkanoates and nonnatural polyesters

SY Choi, IJ Cho, Y Lee, YJ Kim, KJ Kim… - Advanced …, 2020 - Wiley Online Library
Microorganisms produce diverse polymers for various purposes such as storing genetic
information, energy, and reducing power, and serving as structural materials and scaffolds …

Hyperproduction of 3-hydroxypropionate by Halomonas bluephagenesis

XR Jiang, X Yan, LP Yu, XY Liu, GQ Chen - Nature communications, 2021 - nature.com
Hydroxypropionic acid (3HP), an important three carbon (C3) chemical, is designated as
one of the top platform chemicals with an urgent need for improved industrial production …

Metabolism and strategies for enhanced supply of acetyl-CoA in Saccharomyces cerevisiae

Q Zhang, W Zeng, S Xu, J Zhou - Bioresource Technology, 2021 - Elsevier
Acetyl-CoA is a kind of important cofactor that is involved in many metabolic pathways. It
serves as the precursor for many interesting commercial products, such as terpenes …

Metabolic engineering for the production of dicarboxylic acids and diamines

TU Chae, JH Ahn, YS Ko, JW Kim, JA Lee, EH Lee… - Metabolic …, 2020 - Elsevier
Microbial production of chemicals and materials from renewable carbon sources is
becoming increasingly important to help establish sustainable chemical industry. In this …

Depolymerization of polyethylene terephthalate (PET) under mild conditions by Lewis/Brønsted acidic deep eutectic solvents

M Rollo, F Raffi, E Rossi, M Tiecco, E Martinelli… - Chemical Engineering …, 2023 - Elsevier
Modern society urgently needs new recycling methods to handle the impressive amount of
plastic items that are annually discarded. Deep Eutectic Solvents (DESs) have shown …