Simple Summary Synovial sarcoma (SyS) is a rare malignant soft tissue sarcoma bearing
the chromosomal translocation t (X; 18), which encodes the fusion oncoprotein SS18:: SSX …

Trabectedin (TRB) and Lurbinectedin (LUR) are alkaloid compounds originally isolated from
Ecteinascidia turbinata with proven antitumoral activity. Both molecules are structural …

Myxofibrosarcoma (MFS) and undifferentiated pleomorphic sarcoma (UPS) can be
considered as a spectrum of the same disease entity, representing one of the most common …

Myxofibrosarcoma (MFS) is one of the most common adult soft tissue sarcomas, typically
arising in the extremities. Histologically, MFS is classified into three grades: low …

Simple Summary Soft tissue sarcomas represent a large heterogeneous group of malignant
neoplasms that are characterized by a poor disease outcome and being poorly studied …

Traditionally sarcomas have been considered immunologically quiet tumours, with low
tumour mutational burden (TMB) and an immunosuppressive tumour microenvironment …

Immunotherapy has emerged as promising treatment in sarcomas, but the high variability in
terms of histology, clinical behavior and response to treatments determines a particular …

Introduction Sarcomas are classified into two types, bone sarcoma and soft tissue sarcoma
(STS), which account for approximately 1% of adult solid malignancies and 20% of pediatric …

Background Soft tissue sarcoma (STS) is comprised of approximately 80 subtypes, with an
incidence of 4-5 per 100,000 annually in Europe. The National Comprehensive Cancer …

Of the drugs used in second‐line chemotherapy for soft tissue sarcoma (STS), trabectedin is
effective for liposarcoma and leiomyosarcoma (L‐sarcoma), eribulin for liposarcoma, and …