CD45 is an evolutionary highly conserved receptor protein tyrosine phosphatase exclusively
expressed on all nucleated cells of the hematopoietic system. It is characterized by the …

Defensins, a family of cationic, structurally related, antimicrobial peptides, contribute to host
defense by disrupting the cytoplasmic membrane of microbes. Here we show that human …

The deterioration in immune function with aging is thought to make a major contribution to
the increased morbidity and mortality from infectious disease in old age. One aspect of …

CD8+ T lymphocytes play an important role in the control of intracellular pathogens during
both acute and persistent infections. This is particularly true in the case of persistent …

Human cytomegalovirus (HCMV) infection is largely asymptomatic in the immunocompetent
host, but remains a major cause of morbidity in immunosuppressed individuals. Using the …

Human cytomegalovirus (HCMV) infection induces both innate immune responses including
Natural Killer cells as well as adaptive humoral and cell mediated (CD4+ helper, CD8+ …

Vaccinia virus immunization provides lifelong protection against smallpox, but the
mechanisms of this exquisite protection are unknown. We used polychromatic flow cytometry …

The rhesus macaque (RM) is a critical animal model for studies of viral pathogenesis and
immunity, yet fundamental aspects of their cellular immune response remain poorly defined …

In spite of the present belief that latent cytomegalovirus (CMV) infection drives CD8+ T-cell
differentiation and induces premature immune senescence, no systematic studies have so …

Primary virus infection often elicits a large CD8+ T cell response which subsequently
contracts to a smaller memory T cell pool; the relationship between these two virus-specific …