Heparanase is the only mammalian enzyme that cleaves heparan sulphate, an important
component of the extracellular matrix. This leads to the remodelling of the extracellular …

Heparanase has been viewed as a promising anti-cancer drug target for almost two
decades, but no anti-heparanase therapy has yet reached the clinic. This endoglycosidase …

Long noncoding RNAs (lncRNAs) represent a vast unexplored genetic space that may hold
missing drivers of tumourigenesis, but few such “driver lncRNAs” are known. Until now, they …

Heparanase is a β-D-endoglucuronidase that cleaves heparan sulfate, a complex
glycosaminoglycan found ubiquitously throughout mammalian cells and tissues …

Aberrant display of the truncated core1 O-glycan T-antigen is a common feature of human
cancer cells that correlates with metastasis. Here we show that T-antigen in Drosophila …

Background: Patients with breast cancer—the deadliest cancer among women—are at
constant risk of developing metastasis. Oxidative stress and hypoxia are common feature of …

In this chapter, we will emphasize the importance of heparan sulfate proteoglycans (HSPG)
in controlling various physiological and pathological molecular mechanisms and discuss …

Objective The present study describes the clinical and tumor characteristics of patients that
died from differentiated thyroid cancer and reports on the cause and circumstances of death …

Peyronie's disease is characterized by fibrous plaque formation of the tunica albuginea,
causing penile deformity and fertility problems. The aim of the present study was to …

The host enzyme heparanase (HPSE) facilitates the release of herpes simplex virus type 2
(HSV-2) from target cells by cleaving the viral attachment receptor heparan sulfate (HS) from …