Biochemical properties and roles of DprA protein in bacterial natural transformation, virulence, and pilin variation

DK Sharma, HS Misra, SC Bihani… - Journal of …, 2023 - Am Soc Microbiol
Natural transformation enables bacteria to acquire DNA from the environment and
contributes to genetic diversity, DNA repair, and nutritional requirements. DNA processing …

[HTML][HTML] Targeting evolution of antibiotic resistance by SOS response inhibition

A Yakimov, I Bakhlanova, D Baitin - Computational and structural …, 2021 - Elsevier
Antibiotic resistance is acquired in response to antibiotic therapy by activating SOS-
depended mutagenesis and horizontal gene transfer pathways. Compounds able to inhibit …

Pull in and push out: mechanisms of horizontal gene transfer in bacteria

D Sun - Frontiers in microbiology, 2018 - frontiersin.org
Horizontal gene transfer (HGT) plays an important role in bacterial evolution. It is well
accepted that DNA is pulled/pushed into recipient cells by conserved membrane-associated …

Synergic Effects of Temperature and Irradiance on the Physiology of the Marine Synechococcus Strain WH7803

U Guyet, NA Nguyen, H Doré, J Haguait… - Frontiers in …, 2020 - frontiersin.org
Understanding how microorganisms adjust their metabolism to maintain their ability to cope
with short-term environmental variations constitutes one of the major current challenges in …

Liberibacter crescens Is a Cultured Surrogate for Functional Genomics of Uncultured Pathogenic 'Candidatus Liberibacter' spp. and Is Naturally Competent for …

M Jain, L Cai, LA Fleites, A Munoz-Bodnar… - …, 2019 - Am Phytopath Society
'Candidatus Liberibacter'spp. are uncultured insect endosymbionts and phloem-limited
bacterial plant pathogens associated with diseases ranging from severe to nearly …

Structure and properties of a natural competence-associated pilin suggest a unique pilus tip-associated DNA receptor

MZ Salleh, V Karuppiah, M Snee, A Thistlethwaite… - MBio, 2019 - Am Soc Microbiol
Natural competence is the term used to describe the uptake of “naked” extracellular DNA by
bacteria; it plays a significant role in horizontal genetic exchange. It is associated with type …

Building a genome engineering toolbox in nonmodel prokaryotic microbes

E Freed, J Fenster, SL Smolinski… - Biotechnology and …, 2018 - Wiley Online Library
The realization of a sustainable bioeconomy requires our ability to understand and engineer
complex design principles for the development of platform organisms capable of efficient …

Fine‐tuning cellular levels of DprA ensures transformant fitness in the human pathogen Streptococcus pneumoniae

C Johnston, I Mortier‐Barriere, V Khemici… - Molecular …, 2018 - Wiley Online Library
Natural genetic transformation is a widespread mechanism of horizontal gene transfer. It
involves the internalization of exogenous DNA as single strands and chromosomal …

DprA Is Essential for Natural Competence in Riemerella anatipestifer and Has a Conserved Evolutionary Mechanism

L Huang, X Tian, M Liu, M Wang, F Biville… - Frontiers in …, 2019 - frontiersin.org
Riemerella anatipestifer ATCC11845 (RA ATCC11845) is naturally competent. However, the
genes involved in natural transformation in this species remain largely unknown …

Characterization of DNA processing protein A (DprA) of the radiation-resistant bacterium Deinococcus radiodurans

DK Sharma, HS Misra, I Soni… - Microbiology …, 2022 - Am Soc Microbiol
Environmental DNA uptake by certain bacteria and its integration into their genome create
genetic diversity and new phenotypes. DNA processing protein A (DprA) is part of a …