Gut microbiota in interaction with intestinal host tissues influences many brain functions and
microbial dysbiosis has been linked with brain disorders, such as neuropsychiatric …

The antagonistic pleiotropy hypothesis is a well-known evolutionary theory to explain the
aging process. It proposes that while a particular gene may possess beneficial effects during …

The skin is the largest organ of the body. The establishment of immunological memory in the
skin is a crucial component of the adaptive immune response. Once naive T cells are …

The aryl hydrocarbon receptor (AhR) is a widely studied ligand-activated cytosolic
transcriptional factor that has been associated with the initiation and progression of various …

Background Epidemiologic evidence suggests that exposure to particulate matter of 2.5 μm
or less in diameter (PM2. 5) aggravates asthma. Objective We sought to investigate the …

Circadian clocks control the internal sleep-wake rhythmicity of 24 h which is synchronized by
the solar cycle. Circadian regulation of metabolism evolved about 2.5 billion years ago, ie …

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that has
emerged as an important player in asthma control. AhR is responsive to environmental …

There is an under-recognized role of the aryl hydrocarbon receptor (AhR) in co-ordinating
the entry and pathophysiology of the severe acute respiratory syndrome-coronavirus-2 …

Orosomucoid like 3 (ORMDL3) encodes an ER-resident transmembrane protein that
regulates the activity of serine palmitoyltransferase (SPT), the first and rate-limiting enzyme …

The serine palmitoyltransferase (SPT) complex catalyzes the rate-limiting step in the de
novo biosynthesis of ceramides, the precursors of sphingolipids. The mammalian ORMDL …