Understanding organelle biogenesis is a central focus of cell biology. Whereas some are
generated from existing organelles, others can be generated de novo. Most de novo …

Peroxisomes are conserved organelles of eukaryotic cells with important roles in cellular
metabolism, human health, redox homeostasis, as well as intracellular metabolite transfer …

Peroxisomes are organelles that play a central role in lipid metabolism and cellular redox
homeostasis. The import of peroxisomal matrix proteins by peroxisomal targeting signal …

Peroxisomal biogenesis disorders (PBDs) are genetic disorders of peroxisome biogenesis
and metabolism that are characterized by profound developmental and neurological …

Discoveries spanning several decades have pointed to vital membrane lipid trafficking
pathways involving both vesicular and non-vesicular carriers. But the relative contributions …

Organelles within the cell are highly dynamic entities, requiring dramatic morphological
changes to support their function and maintenance. As a result, organelle membranes are …

The peroxisomal membrane protein (PMP) Pex3 and its cytosolic interaction partner Pex19
have been implicated in peroxisomal membrane biogenesis. Although these peroxins have …

Dynamic control of peroxisome proliferation is integral to the peroxisome's many functions.
The endoplasmic reticulum (ER) serves as a source of preperoxisomal vesicles (PPVs) that …

The AAA-ATPases Pex1 and Pex6 are required for the formation and maintenance of
peroxisomes, membrane-bound organelles that harbor enzymes for specialized metabolism …

Peroxisomes are dynamic organelles essential for optimum functioning of a eukaryotic cell.
Biogenesis of these organelles and the diverse functions performed by them have been …