A guide to the organ-on-a-chip

CM Leung, P De Haan… - Nature Reviews …, 2022 - nature.com
Abstract Organs-on-chips (OoCs) are systems containing engineered or natural miniature
tissues grown inside microfluidic chips. To better mimic human physiology, the chips are …

Microfluidic evaporation, pervaporation, and osmosis: from passive pumping to solute concentration

P Bacchin, J Leng, JB Salmon - Chemical Reviews, 2021 - ACS Publications
Evaporation, pervaporation, and forward osmosis are processes leading to a mass transfer
of solvent across an interface: gas/liquid for evaporation and solid/liquid (membrane) for …

Engineered biomimetic membranes for organ-on-a-chip

M Rahimnejad, F Rasouli, S Jahangiri… - ACS Biomaterials …, 2022 - ACS Publications
Organ-on-a-chip (OOC) systems are engineered nanobiosystems to mimic the
physiochemical environment of a specific organ in the body. Among various components of …

Spheroid engineering in microfluidic devices

A Tevlek, S Kecili, OS Ozcelik, H Kulah, HC Tekin - ACS omega, 2023 - ACS Publications
Two-dimensional (2D) cell culture techniques are commonly employed to investigate
biophysical and biochemical cellular responses. However, these culture methods, having …

Microfluidic gut-on-a-chip: fundamentals and challenges

DP Thomas, J Zhang, NT Nguyen, HT Ta - Biosensors, 2023 - mdpi.com
The human gut is responsible for food digestion and absorption. Recently, growing evidence
has shown its vital role in the proper functioning of other organs. Advances in microfluidic …

Integration of extracellular matrices into organ‐on‐chip systems

H Kutluk, EE Bastounis… - Advanced Healthcare …, 2023 - Wiley Online Library
The extracellular matrix (ECM) is a complex, dynamic network present within all tissues and
organs that not only acts as a mechanical support and anchorage point but can also direct …

3D bio-printed hydrogel inks promoting lung cancer cell growth in a lab-on-chip culturing platform

A Krakos, A Cieślak, E Hartel, MB Łabowska… - Microchimica Acta, 2023 - Springer
The results of a lab-on-chip (LOC) platform fabrication equipped with a hydrogel matrix is
reported. A 3D printing technique was used to provide a hybrid,“sandwiched” type structure …

Gut-on-a-Chip Models: Current and Future Perspectives for HostMicrobial Interactions Research

M Morelli, D Kurek, CP Ng, K Queiroz - Biomedicines, 2023 - mdpi.com
The intestine contains the largest microbial community in the human body, the gut
microbiome. Increasing evidence suggests that it plays a crucial role in maintaining overall …

Breaking the clean room barrier: exploring low-cost alternatives for microfluidic devices

CF Rodríguez, V Andrade-Pérez, MC Vargas… - … in Bioengineering and …, 2023 - frontiersin.org
Microfluidics is an interdisciplinary field that encompasses both science and engineering,
which aims to design and fabricate devices capable of manipulating extremely low volumes …

Integrated membranes within centrifugal microfluidic devices: A review

KC O'Connell, JP Landers - Lab on a Chip, 2023 - pubs.rsc.org
Centrifugal microfluidics has evolved into a sophisticated technology capable of enabling
the exploration of fundamental questions in such fields as protein analysis, environmental …