A review of trustworthy and explainable artificial intelligence (xai)

V Chamola, V Hassija, AR Sulthana, D Ghosh… - IEEe …, 2023 - ieeexplore.ieee.org
The advancement of Artificial Intelligence (AI) technology has accelerated the development
of several systems that are elicited from it. This boom has made the systems vulnerable to …

Age-related macular degeneration

M Fleckenstein, TDL Keenan, RH Guymer… - Nature reviews Disease …, 2021 - nature.com
Age-related macular degeneration (AMD) is the leading cause of legal blindness in the
industrialized world. AMD is characterized by accumulation of extracellular deposits, namely …

Highly retina-permeating and long-acting resveratrol/metformin nanotherapeutics for enhanced treatment of macular degeneration

DD Nguyen, LJ Luo, CJ Yang, JY Lai - ACS nano, 2022 - ACS Publications
The development of therapeutics for effective treatments of retinal diseases is significantly
constrained by various biological barriers. We herein report a nanomedicine strategy to …

[HTML][HTML] Rhodopsin, light-sensor of vision

KP Hofmann, TD Lamb - Progress in Retinal and Eye Research, 2023 - Elsevier
The light sensor of vertebrate scotopic (low-light) vision, rhodopsin, is a G-protein-coupled
receptor comprising a polypeptide chain with bound chromophore, 11-cis-retinal, that …

Retina metabolism and metabolism in the pigmented epithelium: a busy intersection

JB Hurley - Annual review of vision science, 2021 - annualreviews.org
The outer retina is nourished from the choroid, a capillary bed just inside the sclera. O2,
glucose, and other nutrients diffuse out of the choroid and then filter through a monolayer of …

[HTML][HTML] Phagocytosis by the retinal pigment epithelium: recognition, resolution, recycling

W Kwon, SA Freeman - Frontiers in immunology, 2020 - frontiersin.org
Tissue-resident phagocytes are responsible for the routine binding, engulfment, and
resolution of their meals. Such populations of cells express appropriate surface receptors …

[HTML][HTML] Cell maturation: Hallmarks, triggers, and manipulation

JR Alvarez-Dominguez, DA Melton - Cell, 2022 - cell.com
How cells become specialized, or" mature," is important for cell and developmental biology.
While maturity is usually deemed a terminal fate, it may be more helpful to consider …

Cell culture models to study retinal pigment epithelium-related pathogenesis in age-related macular degeneration

K Bharti, AI den Hollander, A Lakkaraju, D Sinha… - Experimental eye …, 2022 - Elsevier
Age-related macular degeneration (AMD) is a disease that affects the macula–the central
part of the retina. It is a leading cause of irreversible vision loss in the elderly. AMD onset is …

[HTML][HTML] Dynamic lipid turnover in photoreceptors and retinal pigment epithelium throughout life

D Lewandowski, CL Sander, A Tworak, F Gao… - Progress in retinal and …, 2022 - Elsevier
The retinal pigment epithelium-photoreceptor interphase is renewed each day in a stunning
display of cellular interdependence. While photoreceptors use photosensitive pigments to …

Extracellular vesicles released by human retinal pigment epithelium mediate increased polarised secretion of drusen proteins in response to AMD stressors

M Flores‐Bellver, J Mighty… - Journal of …, 2021 - Wiley Online Library
Age‐related macular degeneration (AMD) is a leading cause of blindness worldwide.
Drusen are key contributors to the etiology of AMD and the ability to modulate drusen …