In the past decade, studies of the human tumour suppressor LKB1 have uncovered a novel
signalling pathway that links cell metabolism to growth control and cell polarity. LKB1 …

▪ Abstract Tight control of cell-cell communication is essential for the generation of a
normally patterned embryo. A critical mediator of key cell-cell signaling events during …

Wnt signaling controls a variety of developmental and homeostatic events. As a key
component of Wnt signaling, Dishevelled (Dvl/Dsh) protein relays Wnt signals from receptors …

Signaling pathways are an ever present force in every animal's life. During development,
these pathways provide critical cell-cell communication required to coordinate the activities …

The majority of bone cell biology focuses on activity on the surface of the bone with little
attention paid to the activity that occurs below the surface. However, with recent new …

The Dishevelled gene was first identified in Drosophila mutants with disoriented hair and
bristle polarity [[1],[2],[3]]. The Dsh gene (Dsh/Dvl, in Drosophila and vertebrates …

Wnt/β-catenin signalling plays essential roles in embryonic development as well as tissue
homoeostasis in adults. Thus abnormal regulation of Wnt/β-catenin signalling is linked to a …

The par genes were discovered in genetic screens for regulators of cytoplasmic partitioning
in the early embryo of C. elegans, and encode six different proteins required for asymmetric …

The c-Jun NH2-terminal kinase (JNK) is a member of an evolutionarily conserved sub-family
of mitogen-activated protein (MAP) kinases. Recent studies have led to progress towards …

Activation of the tumour suppressor p53 by DNA damage induces either cell cycle arrest or
apoptotic cell death. The cytostatic effect of p53 is mediated by transcriptional activation of …