Since its inception nearly a half century ago, CHARMM has been playing a central role in
computational biochemistry and biophysics. Commensurate with the developments in …

Abstract CHARMM-GUI, http://www. charmm-gui. org, is a web-based graphical user
interface to prepare molecular simulation systems and input files to facilitate the usage of …

The serotonin transporter (SERT) regulates neurotransmitter homeostasis through the
sodium-and chloride-dependent recycling of serotonin into presynaptic neurons,–. Major …

The serotonin transporter (SERT) terminates serotonergic signalling through the sodium-and
chloride-dependent reuptake of neurotransmitter into presynaptic neurons. SERT is a target …

Abstract Na+/Cl–-coupled biogenic amine transporters are the primary targets of therapeutic
and abused drugs, ranging from antidepressants to the psychostimulants cocaine and …

Depression is a common mental disorder. The standard medical treatment is the selective
serotonin reuptake inhibitors (SSRIs). All characterized SSRIs are competitive inhibitors of …

The human glycine transporter 1 (GlyT1) regulates glycine-mediated neuronal excitation
and inhibition through the sodium-and chloride-dependent reuptake of glycine,–. Inhibition …

Eukaryotes rely on efficient distribution of energy and carbon skeletons between organs in
the form of sugars. Glucose in animals and sucrose in plants serve as the dominant …

Neurotransmitter/sodium symporters (NSSs) terminate synaptic signal transmission by Na+-
dependent reuptake of released neurotransmitters. Key conformational states have been …

The Amino Acid–Polyamine-Organocation (APC) transporter GadC contributes to the
survival of pathogenic bacteria under extreme acid stress by exchanging extracellular …