Abstract Organs-on-chips (OoCs) are systems containing engineered or natural miniature
tissues grown inside microfluidic chips. To better mimic human physiology, the chips are …

Reactive oxygen species (ROS) are highly reactive chemical species containing oxygen,
controlled by both enzymatic and nonenzymatic antioxidant defense systems. In the heart …

Cardiovascular diseases are the leading cause of death worldwide. Therefore, the discovery
of induced pluripotent stem cells (iPSCs) and the subsequent generation of human induced …

The polymer polydimethylsiloxane (PDMS) is widely used to build microfluidic devices
compatible with cell culture. Whilst convenient in manufacture, PDMS has the disadvantage …

Single cardiomyocytes contain myofibrils that harbor the sarcomere-based contractile
machinery of the myocardium. Cardiomyocytes differentiated from human pluripotent stem …

Cardiomyocytes from human pluripotent stem cells (hPSCs-CMs) could revolutionise
biomedicine. Global burden of heart failure will soon reach USD $90 bn, while unexpected …

The term 'mechanosensation'describes the capacity of cells to translate mechanical stimuli
into the coordinated regulation of intracellular signals, cellular function, gene expression …

Chemotherapy‐induced cardiotoxicity is a serious complication that poses a serious threat
to life and limits the clinical use of various chemotherapeutic agents, particularly the …

Cells generate mechanical forces (traction forces, TFs) while interacting with the
extracellular matrix or neighbouring cells. Forces are generated by both cells and …

Successfully engineering a functional, human, myocardial pump would represent a
therapeutic alternative for the millions of patients with end-stage heart disease and provide …