Histone lactylation bridges metabolic reprogramming and epigenetic rewiring in driving carcinogenesis: Oncometabolite fuels oncogenic transcription

Y Zhang, H Song, M Li, P Lu - Clinical and Translational …, 2024 - Wiley Online Library
Heightened lactate production in cancer cells has been linked to various cellular
mechanisms such as angiogenesis, hypoxia, macrophage polarisation and T‐cell …

Molecular and Functional Key Features and Oncogenic Drivers in Thymic Carcinomas

S Barachini, E Pardini, IS Burzi, G Sardo Infirri… - Cancers, 2023 - mdpi.com
Simple Summary Thymic carcinomas are the most aggressive thymic epithelial tumors.
While thymic carcinomas do not have a single specific cause, various aspects of their growth …

NMR-based metabolomics identification of potential serum biomarkers of disease progression in patients with multiple sclerosis

M Alwahsh, RM Nimer, LA Dahabiyeh, L Hamadneh… - Scientific Reports, 2024 - nature.com
Multiple sclerosis (MS) is a chronic and progressive neurological disorder, characterized by
neuroinflammation and demyelination within the central nervous system (CNS). The etiology …

Metabolic signatures of thymomas: potential biomarkers and treatment targets

JW Miller, BM Faubert, TP Mathews… - European Journal of …, 2024 - academic.oup.com
OBJECTIVES A study of tumour metabolic reprogramming has revealed disease biomarkers
and avenues for therapeutic intervention. Metabolic reprogramming in thymoma is currently …

Metabolomic and transcriptomic profiling identified significant genes in thymic epithelial tumor

E Tang, Y Zhou, S Liu, Z Zhang, R Zhang, D Huang… - Metabolites, 2022 - mdpi.com
Thymomas and thymic carcinomas are malignant thymic epithelial tumors (TETs) with poor
outcomes if non-resectable. However, the tumorigenesis, especially the metabolic …

[HTML][HTML] The Application of Metabolomics in Hyperlipidemia: Insights into Biomarker Discovery and Treatment Efficacy Assessment

M Alwahsh, R Alejel, A Hasan, H Abuzaid, T Al-Qirim - Metabolites, 2024 - mdpi.com
Hyperlipidemia is a lipid metabolism disorder that refers to increased levels of total
triglycerides (TGs), cholesterol (TC), and low-density lipoprotein-cholesterol (LDL-C) and …

Non-Mutational Key Features in the Biology of Thymomas

S Küffer, D Müller, A Marx, P Ströbel - Cancers, 2024 - mdpi.com
Simple Summary Organotypic features such as intratumoral thymopoiesis make thymomas
(THs) unique tumors. Their remarkable histological heterogeneity and low mutational …

Glutathione and Xanthine Metabolic Changes in Tamoxifen Resistant Breast Cancer Cell Lines are Mediated by Down-Regulation of GSS and XDH and Correlated …

M Alwahsh, Y Hamadneh, R Marchan… - Journal of …, 2024 - jcancer.org
Background: Tamoxifen is commonly used in the treatment of hormonal-positive breast
cancer. However, 30%-40% of tumors treated with tamoxifen develop resistance; therefore …

Ultrahigh‐performance liquid chromatography–high‐resolution mass spectrometry‐based plasma metabolomics study of thymoma and thymic hyperplasia

X Zhang, X Zang, H Yang, P Jiao… - Rapid …, 2023 - Wiley Online Library
Rationale Thymoma is a rare malignant tumor but it is the most common primary tumor of the
anterior mediastinum. The current imaging methods for thymoma screening suffer from false …

Characterization of Thymoma by Ultra-Performance Liquid Chromatography—High Resolution Mass Spectrometry (UPLC-HRMS) and Metabolomics of Serum

Y Li, X Zang, P Jiao, X Xue, X Zhang, S Wang… - Analytical …, 2024 - Taylor & Francis
Thymoma is a rare thymic tumor but is the most common anterior mediastinal tumor.
Currently, there are still limitations regarding to its screening and the pathology remains …