Complement is an important component of the innate immune system that is crucial for
defense from microbial infections and for clearance of immune complexes and injured cells …

Haemolytic uraemic syndrome (HUS) and thrombotic thrombocytopaenic purpura (TTP) are
diseases characterized by microvascular thrombosis, with consequent thrombocytopaenia …

Background Vascular leakage and shock are the major causes of death in patients with
dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Thirty years ago …

Activation of the complement system is a major pathogenic event that drives various
inflammatory responses in numerous diseases. All pathways of complement activation lead …

We monitored the number of intravascular platelet-leukocyte aggregates (PLAs) and
thrombotic occlusions (TOs) by intravascular microscopy in the mesentery of rats receiving …

To assess the sensitivity of primary non-Hodgkin lymphoma cells to rituximab-mediated
cytotoxicity, we compared the potency of several rituximab-mediated killing mechanisms on …

Purpose: The use of the CD20-specific antibody rituximab has greatly improved the
response to treatment of CD20+ follicular lymphoma. Despite the success of rituximab …

The complement and hemostatic systems are complex systems, and both involve enzymatic
cascades, regulators, and cell components—platelets, endothelial cells, and immune cells …

The long pentraxin PTX3 is a multifunctional soluble molecule involved in inflammation and
innate immunity. As an acute phase protein, PTX3 binds to the classical pathway …

The complement system plays a double role in pregnancy exerting both protective and
damaging effects at placental level. Complement activation at fetal-maternal interface …