Cells and organisms must coordinate their metabolic activity with changes in their
environment to ensure their growth only when conditions are favourable. In order to maintain …

The mechanistic target of rapamycin complex 1 (mTORC1) coordinates cellular growth and
metabolism with environmental inputs to ensure that cells grow only under favourable …

Rationale: Idiopathic pulmonary fibrosis (IPF) is an insidious and fatal interstitial lung
disease associated with declining pulmonary function. Accelerated aging, loss of epithelial …

The phytochemical epigallocatechin gallate (EGCG) has been reported to alleviate age-
associated immune disorders and organ dysfunction. However, information regarding the …

Disrupted myelin and impaired myelin repair have been observed in the brains of patients
and various mouse models of Alzheimer's disease (AD). Clemastine, an H1-antihistamine …

Cellular senescence is a complex physiological state whose main feature is proliferative
arrest. Cellular senescence can be considered the reverse of cell immortalization and …

Abstract Information regarding cellular anti-senescence attributes of probiotic bacteria vis-à-
vis modulation of senescence-associated secretory phenotype (SASP) and mTOR signaling …

Mammalian autophagy is a highly regulated and conserved cellular homeostatic process. Its
existence allows the degradation of self‐components to mediate cell survival in different …

Selective degradation of damaged mitochondria by autophagy (mitophagy) is proposed to
play an important role in cellular homeostasis. However, the molecular mechanisms and the …

Obesity is the major risk factor for the development of cardiovascular diseases like
hypertension, coronary artery disease, atrial fibrillation, and chronic heart failure. It is …