Excessive fear and anxiety are hallmarks of a variety of disabling anxiety disorders that
affect millions of people throughout the world. Hence, a greater understanding of the brain …

Considerable evidence suggests that the formation of long-term memories requires a critical
period of new protein synthesis. Recently, the notion that some of these newly synthesized …

Activity-dependent changes in the strength of synaptic connections are fundamental to the
formation and maintenance of memory. The mechanisms underlying persistent changes in …

Beyond the well-known function of poly (A) tail length in mRNA stability, recent years have
witnessed an explosion of information about how changes in tail length and the selection of …

Many cellular functions require the synthesis of a specific protein or functional cohort of
proteins at a specific time and place in the cell. Local protein synthesis in neuronal dendrites …

Nearly two decades ago, Xenopus oocytes were found to contain mRNAs harboring a small
sequence in their 3′ untranslated regions that control cytoplasmic polyadenylation and …

Translation of localized mRNA is a fast and efficient way of reacting to extracellular stimuli
with the added benefit of providing spatial resolution to the cellular response. The efficacy of …

Synaptic transmission in neurons is a measure of communication at synapses, the points of
contact between axons and dendrites. The magnitude of synaptic transmission is a reflection …

The cytoplasmic polyadenylation element binding (CPEB) proteins are sequence-specific
mRNA binding proteins that control translation in development, health, and disease. CPEB1 …

Both long-term behavioral memory and synaptic plasticity require protein synthesis, some of
which may occur locally at specific synapses. Cytoplasmic polyadenylation element–binding …