Local and systemic hypoxia as inductors of increased aluminum and iron brain accumulation promoting the onset of Alzheimer's disease

A Cirovic, A Cirovic, OE Orisakwe, RR Lima - Biological Trace Element …, 2023 - Springer
Human environment is highly contaminated with aluminum, and aluminum is toxic to
majority of tissues, particularly to neurons. In previous decades, aluminum exposure was …

Aluminum induced immunoexcitotoxicity in neurodevelopmental and neurodegenerative disorders

RL Blaylock - Current Inorganic Chemistry (Discontinued), 2012 - ingentaconnect.com
A great deal has been learned about the neurotoxicity of aluminum over the past two
decades in terms of its ability to disrupt cellular function. Newer evidence suggests that a …

Molecular mechanisms of aluminum neurotoxicity: Update on adverse effects and therapeutic strategies

AV Skalny, M Aschner, Y Jiang, YG Gluhcheva… - Advances in …, 2021 - Elsevier
Recent studies have demonstrated that brain may be considered as the target for aluminium
(Al) toxicity, resulting in development of neurodegenerative and neurodevelopmental …

Effect of long-term exposure to aluminum on the acetylcholinesterase activity in the central nervous system and erythrocytes

RR Kaizer, MC Correa, LRS Gris, CS Da Rosa… - Neurochemical …, 2008 - Springer
Aluminum (Al), a neurotoxic agent, has been associated with Alzheimer's disease (AD),
which is characterized by cholinergic dysfunction in the central nervous system. In this study …

Does neurotransmission impairment accompany aluminium neurotoxicity?

PP Gonçalves, VS Silva - Journal of Inorganic Biochemistry, 2007 - Elsevier
Neurobehavioral disorders, except their most overt form, tend to lie beyond the reach of
clinicians. Presently, the use of molecular data in the decision-making processes is limited …

Melatonin reduces oxidative damage induced by aluminium in rat kidney

S Mahieu, M del Carmen Contini, M González… - Toxicology Letters, 2009 - Elsevier
We evaluated the effect of melatonin (Mel), in male Wistar rats which received aluminium
(Al) lactate for 12 weeks (0.57 mg Al/100g body weight (bw), ip three times per week) …

Studies on fate and toxicity of nanoalumina in male albino rats: oxidative stress in the brain, liver and kidney

GM Morsy, KS Abou El-Ala… - Toxicology and industrial …, 2016 - journals.sagepub.com
The present work aimed to evaluate the oxidative stress of nanoalumina (aluminium oxide
nanoparticles, Al2O3-NPs) with a diameter< 13 nm (9.83±1.61 nm) as assessed by the …

Aluminum chloride causes the dysfunction of testes through inhibiting the ATPase enzyme activities and gonadotropin receptor expression in rats

X Sun, H Sun, K Yu, Z Wang, Y Liu, K Liu… - Biological trace element …, 2018 - Springer
The aim of this experiment is to explore the effects of aluminum chloride (AlCl 3) on the
ATPase enzymes and gonadotropin receptors in the testes. Eighty male Wistar rats were …

Impacts of short-term acid and aluminum exposure on Atlantic salmon (Salmo salar) physiology: a direct comparison of parr and smolts

MY Monette, SD McCormick - Aquatic Toxicology, 2008 - Elsevier
Episodic acidification resulting in increased acidity and inorganic aluminum (Ali) is known to
impact anadromous salmonids and has been identified as a possible cause of Atlantic …

Protective effect of selenium on aluminium-induced oxidative stress in mouse liver in vivo

D Viezeliene, E Jansen, H Rodovicius… - environmental …, 2011 - Elsevier
The aim of the study was to evaluate possible protective effects of selenium (Se) against
systemic aluminium (Al) toxicity and the redox status of mouse liver after short-term (16h) …