Prime editor (PE), which is developed by combining Cas9 nickase and an engineered
reverse transcriptase, can mediate all twelve types of base substitutions and small insertions …

Nonsense-mediated mRNA decay (NMD) is a cellular surveillance mechanism that
degrades mRNAs with a premature stop codon, avoiding the synthesis of C-terminally …

The exon junction complex (EJC) becomes an increasingly important regulator of early gene
expression in the central nervous system (CNS) and other tissues. The EJC is comprised of …

Nonsense‐mediated mRNA decay (NMD) is governed by the three conserved factors—
UPF1, UPF2, and UPF3. While all three are required for NMD in yeast, UPF3B is …

The paralogous human proteins UPF3A and UPF3B are involved in recognizing mRNAs
targeted by nonsense‐mediated mRNA decay (NMD). UPF3B has been demonstrated to …

Synonymous gene recoding, the substitution of synonymous variants into the genetic
sequence, has been used to overcome many production limitations in therapeutic …

Autism Spectrum Disorder (ASD) is a heterogeneous neurodevelopmental condition with
unclear etiology. Many genes have been associated with ASD risk, but the underlying …

Abstract Background Helsmoortel–Van der Aa syndrome is a neurodevelopmental disorder
in which patients present with autism, intellectual disability, and frequent extra-neurological …

UPF3B encodes the Regulator of nonsense transcripts 3B protein, a core‐member of the
nonsense‐mediated mRNA decay pathway, protecting the cells from the potentially …

Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that is conserved
across all eukaryotes ensuring the quality of transcripts by targeting messenger RNA …