[HTML][HTML] Extracellular vesicles versus lipid nanoparticles for the delivery of nucleic acids
J Bader, F Brigger, JC Leroux - Advanced Drug Delivery Reviews, 2024 - Elsevier
Extracellular vesicles (EVs) are increasingly investigated for delivering nucleic acid (NA)
therapeutics, leveraging their natural role in transporting NA and protein-based cargo in cell …
therapeutics, leveraging their natural role in transporting NA and protein-based cargo in cell …
[HTML][HTML] Nano-encapsulation and conjugation applied in the development of lipid nanoparticles delivering nucleic acid materials to enable gene therapies
L Dinh, L Mahon, B Yan - Applied Nano, 2024 - mdpi.com
Nano-encapsulation and conjugation are the main strategies employed for drug delivery.
Nanoparticles help improve encapsulation and targeting efficiency, thus optimizing …
Nanoparticles help improve encapsulation and targeting efficiency, thus optimizing …
Tetrahydropyrimidine Ionizable Lipids for Efficient mRNA Delivery
I Isaac, A Shaikh, M Bhatia, Q Liu, S Park… - ACS …, 2024 - ACS Publications
Lipid nanoparticles (LNPs) have emerged as an effective and promising technology for
messenger RNA (mRNA) delivery, offering a potential solution to physiological barriers and …
messenger RNA (mRNA) delivery, offering a potential solution to physiological barriers and …
[HTML][HTML] NMR-based analysis of impact of siRNA mixing conditions on internal structure of siRNA-loaded LNP
K Ueda, Y Sakagawa, T Saito, F Sakuma… - Journal of Controlled …, 2024 - Elsevier
This study aimed to assess the applicability of solution-state 1 H NMR for molecular-level
characterization of siRNA-loaded lipid nanoparticles (LNP). Dilinoleylmethyl-4 …
characterization of siRNA-loaded lipid nanoparticles (LNP). Dilinoleylmethyl-4 …
[HTML][HTML] Endosomal escape mechanisms of extracellular vesicle-based drug carriers: lessons for lipid nanoparticle design
L Hagedorn, DC Jürgens, OM Merkel… - Extracellular …, 2024 - pmc.ncbi.nlm.nih.gov
The rise of biologics and RNA-based therapies challenges the limitations of traditional drug
treatments. However, these potent new classes of therapeutics require effective delivery …
treatments. However, these potent new classes of therapeutics require effective delivery …
Ionizable polymeric micelles (IPMs) for efficient siRNA delivery
Z Zhou, Y Feng, M Jiang, Z Yao, J Wang, F Pan… - Nature …, 2025 - nature.com
Lipid nanoparticles (LNPs) are widely used for nucleic acid delivery but face challenges like
limited targeting and accelerated blood clearance (ABC) effect. We design three ionizable …
limited targeting and accelerated blood clearance (ABC) effect. We design three ionizable …
Development of an extended action fostemsavir lipid nanoparticle
An extended action fostemsavir (FTR) lipid nanoparticle (LNP) formulation prevents human
immunodeficiency virus type one (HIV-1) infection. This FTR formulation establishes a drug …
immunodeficiency virus type one (HIV-1) infection. This FTR formulation establishes a drug …
Lyotropic Liquid Crystalline Phase Nanostructure and Cholesterol Enhance Lipid Nanoparticle Mediated mRNA Transfection in Macrophages
J Iscaro, H Yu, N Martinez… - Advanced Functional …, 2024 - Wiley Online Library
Macrophages are unique immune cells attracting growing attention as a potential candidate
for cell‐based therapy for infectious diseases and cancer. Strategies that can reprogramme …
for cell‐based therapy for infectious diseases and cancer. Strategies that can reprogramme …
[HTML][HTML] Amphiphilic Lipids for Food Functionality
RVM Freire, S Salentinig - Current Opinion in Colloid & Interface Science, 2024 - Elsevier
Amphiphilic lipids are essential biomolecules, critical components in nature's functional
materials, and crucial nutrients in food. Being sustainable, biocompatible, and …
materials, and crucial nutrients in food. Being sustainable, biocompatible, and …
A renal-targeted gene delivery system derived from spermidine for arginase-2 silencing and synergistic attenuation of drug-induced acute kidney injury
XR Gu, K Liu, YX Deng, BX Xiang, LY Zhou… - Chemical Engineering …, 2024 - Elsevier
Drug-induced acute kidney injury (DI-AKI) presents a substantial clinical challenge with
limited therapeutic options. This study investigate the potential of arginase-2 (Arg-2) as a …
limited therapeutic options. This study investigate the potential of arginase-2 (Arg-2) as a …