Meteorin-like/Metrnl, a novel secreted protein implicated in inflammation, immunology, and metabolism: A comprehensive review of preclinical and clinical studies

Z Li, Z Gao, T Sun, S Zhang, S Yang, M Zheng… - Frontiers in …, 2023 - frontiersin.org
Meteorin-like, also known as Metrnl, Meteorin-β, Subfatin, and Cometin, is a novel secreted
protein exerting pleiotropic effects on inflammation, immunology, and metabolism. Earlier …

New discovered adipokines associated with the pathogenesis of obesity and type 2 diabetes

JX Cheng, K Yu - … , metabolic syndrome and obesity: targets and …, 2022 - Taylor & Francis
Obesity is defined as abnormal or excessive accumulation of adipose tissue, closely
associated with the increased risk of various comorbidities, especially type 2 diabetes …

The role of adipokines in osteoporosis management: a mini review

JD Patil, S Fredericks - Frontiers in Endocrinology, 2024 - frontiersin.org
The prevalence of osteoporosis has been on the rise globally. With ageing populations,
research has sought therapeutic solutions in novel areas. One such area is that of the …

[HTML][HTML] Type 2 diabetes and bone fragility in children and adults

MF Faienza, P Pontrelli, G Brunetti - World Journal of Diabetes, 2022 - ncbi.nlm.nih.gov
Abstract Type 2 diabetes (T2D) is a global epidemic disease. The prevalence of T2D in
adolescents and young adults is increasing alarmingly. The mechanisms leading to T2D in …

[HTML][HTML] Inhibition of SPARC signal by aerobic exercise to ameliorate atherosclerosis

S Hu, X Zhang, Y Ding, X Liu, R Xia, X Wang - International …, 2024 - Elsevier
Background and aims Inflammation and atherosclerosis (AS) are closely associated to
Secreted Protein Acidic and Rich in Cysteine (SPARC) and its related factors. This study …

Myokines: metabolic regulation in obesity and type 2 diabetes

ZT Chen, ZX Weng, JD Lin, ZX Meng - Life Metabolism, 2024 - academic.oup.com
Skeletal muscle plays a vital role in the regulation of systemic metabolism, partly through its
secretion of endocrine factors which are collectively known as myokines. Altered myokine …

Ethnic Variations in the Levels of Bone Biomarkers (Osteoprostegerin, Receptor Activator of Nuclear Factor Kappa-Β Ligand and Glycoprotein Non-Metastatic …

P Cherian, I Al-Khairi, M Abu-Farha, T Alramah… - Biomedicines, 2024 - mdpi.com
The global incidence of Type 2 diabetes (T2D) is on the rise, fueled by factors such as
obesity, sedentary lifestyles, socio-economic factors, and ethnic backgrounds. T2D is a …

The Function and Mechanism of Anti-Inflammatory Factor Metrnl Prevents the Progression of Inflammatory-Mediated Pathological Bone Osteolytic Diseases

N Liu, J Dong, L Li, D Zhou, F Liu - Journal of Inflammation …, 2024 - Taylor & Francis
Metrnl, recently identified as an adipokine, is a secreted protein notably expressed in white
adipose tissue, barrier tissues, and activated macrophages. This adipokine plays a pivotal …

Can irisin be developed as the molecular evolutionary clock based on the origin and functions?

J Chen, L Guo, C Wang, P Peng, J Wu, H Zhang… - General and …, 2024 - Elsevier
Irisin, a myokine identified in 2012, has garnered research interest for its capacity to induce
browning of adipocytes and improve metabolic parameters. As such, the potential …

Evaluation of the effects of systemic irisin application on guided bone regeneration in peri-implant bone defects

O Bulmus, S Dundar, A Bozoglan, G Artas… - Journal of …, 2022 - journals.lww.com
This study aimed to investigate the effects of systemic irisin hormone application on new
bone formation in peri-implant bone defects. After surgically creating peri-implant bone …