Cardiovascular disease (CVD) remains a global economic burden even in the 21st century
with 85% of deaths resulting from heart attacks. Despite efforts in reducing the risk factors …

AT2 cells harbor alveolar stem cell activity in the lung and can self-renew and differentiate
into AT1 cells during homeostasis and after injury. To identify epigenetic pathways that …

Stem cells often possess immature mitochondria with few inner membrane invaginations,
which increase as stem cells differentiate. Despite this being a conserved feature across …

Background Induced pluripotent stem cells (iPSCs)-derived kidney organoids are a
promising model for studying disease mechanisms and renal development. Despite several …

Mitochondrial diseases are difficult to treat due to the complexity and multifaceted nature of
mitochondrial dysfunction. Brain organoids are three-dimensional (3D) structures derived …

Human induced pluripotent stem cells (iPSCs) hold great promise for reducing the mortality
of cardiovascular disease by cellular replacement of infarcted cardiomyocytes (CMs). CM …

The integration of cell metabolism with signalling pathways, transcription factor networks
and epigenetic mediators is critical in coordinating molecular and cellular events during …

Germ cells act as the carriers of genetic information and are vital in the propagation of a
sexually reproducing species. Furthermore, oocytes establish early embryonic development …