Gliomas are the common type of brain tumors originating from glial cells. Epidemiologically,
gliomas occur among all ages, more often seen in adults, which males are more susceptible …

Brain tumors, although rare, contribute to distinct mortality and morbidity at all ages.
Although there are few therapeutic options for brain tumors, enhanced biological …

Neurofibromin is a large and multifunctional protein encoded by the tumor suppressor gene
NF1, mutations of which cause the tumor predisposition syndrome neurofibromatosis type 1 …

The wide variety of clinical manifestations of the genetic syndrome neurofibromatosis type 1
(NF1) are driven by overactivation of the RAS pathway. Mitogen-activated protein kinase …

Purpose: PNOC003 is a multicenter precision medicine trial for children and young adults
with newly diagnosed diffuse intrinsic pontine glioma (DIPG). Patients and Methods: Patients …

Neurofibromatosis type 1 is a rare neurogenetic syndrome, characterized by pigmentary
abnormalities, learning and social deficits, and a predisposition for benign and malignant …

Gliomas arising in the setting of neurofibromatosis type 1 (NF1) are heterogeneous,
occurring from childhood through adulthood, can be histologically low-grade or high-grade …

Abstract pLGGs are a group of tumors for which the era of molecular diagnostics has truly
shifted treatment paradigms and patient care. The discovery that this group of tumors is …

Background Pediatric low-grade gliomas (pLGGs) are the most common central nervous
system tumor in children, characterized by RAS/MAPK pathway driver alterations. Genomic …

PURPOSE The PNOC001 phase II single-arm trial sought to estimate progression-free
survival (PFS) associated with everolimus therapy for progressive/recurrent pediatric low …