Therapeutic targeting of the angiopoietin–TIE pathway

P Saharinen, L Eklund, K Alitalo - Nature Reviews Drug Discovery, 2017 - nature.com
The endothelial angiopoietin (ANG)–TIE growth factor receptor pathway regulates vascular
permeability and pathological vascular remodelling during inflammation, tumour …

Osteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin

D Andreev, M Liu, D Weidner, K Kachler… - The Journal of …, 2020 - Am Soc Clin Investig
Although the control of bone-resorbing osteoclasts through osteocyte-derived RANKL is well
defined, little is known about the regulation of osteoclasts by osteocyte death. Indeed …

Mesenchymal stem cell printing and process regulated cell properties

J Snyder, AR Son, Q Hamid, C Wang, Y Lui… - Biofabrication, 2015 - iopscience.iop.org
This topical review with original analysis and empirical results compares cell sensitivity to
physical stress during printing. The objective is to frame a reproducible causation between …

SIRT6 Prevents Glucocorticoid‐Induced Osteonecrosis of the Femoral Head in Rats

L Fang, G Zhang, Y Wu, Z Li, S Gao… - Oxidative Medicine and …, 2022 - Wiley Online Library
Objective. Glucocorticoid‐induced osteonecrosis of the femoral head is one of the most
common causes of nontraumatic osteonecrosis of the femoral head, but its exact …

[HTML][HTML] Analysis of early stage osteonecrosis of the human femoral head and the mechanism of femoral head collapse

C Wang, H Meng, Y Wang, B Zhao, C Zhao… - … journal of biological …, 2018 - ncbi.nlm.nih.gov
We explored the mechanism of early stage osteonecrotic femoral head collapse by
analyzing and comparing different regions in human osteonecrotic femoral head samples …

[HTML][HTML] Metformin coordinates osteoblast/osteoclast differentiation associated with ischemic osteonecrosis

SH Park, MA Kang, YJ Moon, KY Jang… - Aging (Albany NY), 2020 - ncbi.nlm.nih.gov
In this study, we aimed to identify a candidate drug that can activate endogenous
Angiopoietin 1 (Ang1) expression via drug repositioning as a pharmacological treatment for …

[HTML][HTML] Epidermal growth factor (EGF) promotes bone healing in surgically induced osteonecrosis of the femoral head (ONFH)

O Basal, T Atay, İM Ciris, YB Baykal - Bosnian Journal of Basic …, 2018 - ncbi.nlm.nih.gov
Angiogenic effects of epidermal growth factor (EGF), a potent mitogen, have been
demonstrated previously. Moreover, different in vitro studies showed that EGF affects …

[HTML][HTML] Angiogenesis of Avascular Necrosis of the Femoral Head: A Classic Treatment Strategy

P Wang, W Shao, Y Wang, B Wang, X Lv, Y Feng - Biomedicines, 2024 - mdpi.com
Avascular necrosis of the femoral head (ANFH) is a type of osteonecrosis due to the
cessation of blood supply, characterized by persistent local pain and collapse of the joint …

Interferon β protects against avascular osteonecrosis through interleukin 6 inhibition and silent information regulator transcript-1 upregulation

KM Kim, S Wagle, YJ Moon, SI Wang, BH Park… - …, 2017 - pmc.ncbi.nlm.nih.gov
Synovitis of the affected joint is a common in avascular osteonecrosis (AVN). Increased
levels of pro-inflammatory cytokine interleukin-6 (IL-6) have been reported in AVN, but the …

成骨分化与修复调控转录因子Runx2 在股骨头坏死组织中的表达: 非随机平行对照临床观察试验方案

杨礼庆, 董成建, 朱姝 - 中国组织工程研究, 2016 - cjter.com
摘要背景: 股骨头血供中断或受损引起骨细胞及骨髓成分死亡引发股骨头坏死.
多种成骨相关因子如Runt 相关转录因子2 (Runx2), 骨形态发生蛋白, 骨保护素, 骨钙素 …