[HTML][HTML] Transplantation of photoreceptors into the degenerative retina: Current state and future perspectives
The mammalian retina displays no intrinsic regenerative capacities, therefore retinal
degenerative diseases such as age-related macular degeneration (AMD) or retinitis …
degenerative diseases such as age-related macular degeneration (AMD) or retinitis …
Autologous induced pluripotent stem cell–based cell therapies: Promise, progress, and challenges
M Madrid, C Sumen, S Aivio, N Saklayen - Current protocols, 2021 - Wiley Online Library
The promise of human induced pluripotent stem cells (iPSCs) lies in their ability to serve as
a starting material for autologous, or patient‐specific, stem cell–based therapies. Since the …
a starting material for autologous, or patient‐specific, stem cell–based therapies. Since the …
Reproducibility and staging of 3D human retinal organoids across multiple pluripotent stem cell lines
EE Capowski, K Samimi, SJ Mayerl… - …, 2019 - journals.biologists.com
Numerous protocols have been described for producing neural retina from human
pluripotent stem cells (hPSCs), many of which are based on the culture of 3D organoids …
pluripotent stem cells (hPSCs), many of which are based on the culture of 3D organoids …
Retinoblastoma from human stem cell-derived retinal organoids
Retinoblastoma is a childhood cancer of the developing retina that initiates with biallelic
inactivation of the RB1 gene. Children with germline mutations in RB1 have a high …
inactivation of the RB1 gene. Children with germline mutations in RB1 have a high …
Clinically focused molecular investigation of 1000 consecutive families with inherited retinal disease
Purpose To devise a comprehensive multiplatform genetic testing strategy for inherited
retinal disease and to describe its performance in 1000 consecutive families seen by a …
retinal disease and to describe its performance in 1000 consecutive families seen by a …
Characterization and transplantation of CD73-positive photoreceptors isolated from human iPSC-derived retinal organoids
G Gagliardi, KB M'Barek, A Chaffiol… - Stem Cell Reports, 2018 - cell.com
Photoreceptor degenerative diseases are a major cause of blindness for which cell
replacement is one of the most encouraging strategies. For stem cell-based therapy using …
replacement is one of the most encouraging strategies. For stem cell-based therapy using …
Using CRISPR-Cas9 to generate gene-corrected autologous iPSCs for the treatment of inherited retinal degeneration
Patient-derived induced pluripotent stem cells (iPSCs) hold great promise for autologous
cell replacement. However, for many inherited diseases, treatment will likely require genetic …
cell replacement. However, for many inherited diseases, treatment will likely require genetic …
Photoreceptor cell replacement in macular degeneration and retinitis pigmentosa: a pluripotent stem cell-based approach
G Gagliardi, KB M'Barek, O Goureau - Progress in retinal and eye research, 2019 - Elsevier
The human retina fails to regenerate and cell-based therapies offer options for treatment of
blinding retinal diseases, such as macular degeneration and retinitis pigmentosa. The last …
blinding retinal diseases, such as macular degeneration and retinitis pigmentosa. The last …
Drug screening for human genetic diseases using iPSC models
Induced pluripotent stem cells (iPSCs) enable the generation of previously unattainable,
scalable quantities of disease-relevant tissues from patients suffering from essentially any …
scalable quantities of disease-relevant tissues from patients suffering from essentially any …
Restoration of visual function by transplantation of optogenetically engineered photoreceptors
A major challenge in the treatment of retinal degenerative diseases, with the transplantation
of replacement photoreceptors, is the difficulty in inducing the grafted cells to grow and …
of replacement photoreceptors, is the difficulty in inducing the grafted cells to grow and …