Microtubule dynamics and their control are essential for the normal function and division of
all eukaryotic cells. This plethora of functions is, in large part, supported by dynamic …

Microtubules are core components of the eukaryotic cytoskeleton with essential roles in cell
division, shaping, motility and intracellular transport. Despite their functional heterogeneity …

Microtubules are dynamic polymers of αβ-tubulin that are essential for intracellular
organization, organelle trafficking and chromosome segregation. Microtubule growth and …

Microtubule-targeting agents (MTAs) such as paclitaxel and the vinca alkaloids are among
the most important medical weapons available to combat cancer. MTAs interfere with …

Microtubules are long, slender polymers of αβ-tubulin found in all eukaryotic cells. Tubulins
associate longitudinally to form protofilaments, and adjacent protofilaments associate …

Microtubules (MTs) are polymers assembled from αβ-tubulin heterodimers that display the
hallmark behavior of dynamic instability. MT dynamics are driven by GTP hydrolysis within …

In living cells, microtubules (MTs) play pleiotropic roles, which require very different
mechanical properties. Unlike the dynamic MTs found in the cytoplasm of metazoan cells …

The dynamic instability of microtubules is a conserved and fundamental mechanism in
eukaryotes. Yet microtubules from different species diverge in their growth rates, lattice …

The conserved Ndc80 kinetochore complex, Ndc80c, is the principal link between mitotic
spindle microtubules and centromere-associated proteins. We used AlphaFold 2 (AF2) to …

Microtubule (MT) filaments, composed of α/β-tubulin dimers, are fundamental to cellular
architecture, function and organismal development. They are nucleated from MT organizing …