The arrival of multicellularity in evolution facilitated cell–cell signaling in conjunction with
adhesion. As the ectodomains of cadherins interact with each other directly in trans (as well …

Mammalian spermatogenesis, a complex process that involves the movement of developing
germ cells across the seminiferous epithelium, entails extensive restructuring of Sertoli …

Simple Summary Colorectal cancer is the second leading cause of cancer-related death in
the world. Upregulation of fatty acid metabolism is a hallmark of cancer and recent studies …

Tumor metastasis involves cancer cell invasion across basement membranes and interstitial
tissues. The initial invasion step consists of adherence of the tumor cell to the extracellular …

Single-cell RNA sequencing (scRNA-Seq) provides a valuable platform for characterising
multicellular ecosystems. Fibroblasts are a heterogeneous cell type involved in many …

Summary Protocadherin-19 (PCDH19) is a synaptic cell-adhesion molecule encoded by X-
linked PCDH19, a gene linked with epilepsy. Here, we report a synapse-to-nucleus …

Background N-cadherin is a trans-membrane adhesion molecule associated with advanced
carcinoma progression and poor prognosis. The effect of N-cadherin on matrix …

Matrix metalloproteinases (MMPs) influence synaptic recovery following traumatic brain
injury (TBI). Membrane type 5-matrix metalloproteinase (MT5-MMP) and ad istintegrin a nd …

Talin is a large scaffolding molecule that plays a major role in integrin-dependent cell–matrix
adhesion. A role for talin in cell–cell attachment through cadherin has never been …

The epithelial-to-mesenchymal transition (EMT) is a highly coordinated process underlying
both development and disease. Premigratory neural crest cells undergo EMT, migrate away …