HOCOMOCO: towards a complete collection of transcription factor binding models for human and mouse via large-scale ChIP-Seq analysis

IV Kulakovskiy, IE Vorontsov, IS Yevshin… - Nucleic acids …, 2018 - academic.oup.com
We present a major update of the HOCOMOCO collection that consists of patterns
describing DNA binding specificities for human and mouse transcription factors. In this …

GTRD: a database on gene transcription regulation—2019 update

I Yevshin, R Sharipov, S Kolmykov… - Nucleic acids …, 2019 - academic.oup.com
The current version of the Gene Transcription Regulation Database (GTRD; http://gtrd.
biouml. org) contains information about:(i) transcription factor binding sites (TFBSs) and …

HOCOMOCO in 2024: a rebuild of the curated collection of binding models for human and mouse transcription factors

IE Vorontsov, IA Eliseeva, A Zinkevich… - Nucleic Acids …, 2024 - academic.oup.com
We present a major update of the HOCOMOCO collection that provides DNA binding
specificity patterns of 949 human transcription factors and 720 mouse orthologs. To make …

Multifunctional role of the transcription factor Blimp-1 in coordinating plasma cell differentiation

M Minnich, H Tagoh, P Bönelt, E Axelsson… - Nature …, 2016 - nature.com
The transcription factor Blimp-1 is necessary for the generation of plasma cells. Here we
studied its functions in plasmablast differentiation by identifying regulated Blimp-1 target …

GTRD: a database of transcription factor binding sites identified by ChIP-seq experiments

I Yevshin, R Sharipov, T Valeev, A Kel… - Nucleic acids …, 2016 - academic.oup.com
Abstract GTRD—Gene Transcription Regulation Database (http://gtrd. biouml. org)—is a
database of transcription factor binding sites (TFBSs) identified by ChIP-seq experiments for …

Histone-fold domain protein NF-Y promotes chromatin accessibility for cell type-specific master transcription factors

AJ Oldfield, P Yang, AE Conway, S Cinghu… - Molecular cell, 2014 - cell.com
Cell type-specific master transcription factors (TFs) play vital roles in defining cell identity
and function. However, the roles ubiquitous factors play in the specification of cell identity …

Nitrogen stress response and stringent response are coupled in Escherichia coli

DR Brown, G Barton, Z Pan, M Buck… - Nature …, 2014 - nature.com
Assimilation of nitrogen is an essential process in bacteria. The nitrogen regulation stress
response is an adaptive mechanism used by nitrogen-starved Escherichia coli to scavenge …

Structures and nucleic acid-binding preferences of the eukaryotic ARID domain

SM Korn, A Schlundt - Biological Chemistry, 2022 - degruyter.com
The DNA-binding AT-rich interactive domain (ARID) exists in a wide range of proteins
throughout eukaryotic kingdoms. ARID domain-containing proteins are involved in manifold …

Human promoters are intrinsically directional

SHC Duttke, SA Lacadie, MM Ibrahim, CK Glass… - Molecular cell, 2015 - cell.com
Divergent transcription, in which reverse-oriented transcripts occur upstream of eukaryotic
promoters in regions devoid of annotated genes, has been suggested to be a general …

RORγ directly regulates the circadian expression of clock genes and downstream targets in vivo

Y Takeda, R Jothi, V Birault, AM Jetten - Nucleic acids research, 2012 - academic.oup.com
In this study, we demonstrate that the lack of retinoic acid-related orphan receptor (ROR) γ or
α expression in mice significantly reduced the peak expression level of Cry1, Bmal1, E4bp4 …