The cytoskeleton and its components—actin, microtubules and intermediate filaments—
have been studied for decades, and multiple roles of the individual cytoskeletal …

Recent observations related to the structure of the cytoskeleton in neurons and novel
cytoskeletal abnormalities involved in the pathophysiology of some neurological diseases …

The development of a functional nervous system entails establishing connectivity between
appropriate synaptic partners. During axonal pathfinding, the developing axon navigates …

The canonical Wnt/β-catenin pathway is a highly conserved signaling cascade that plays
critical roles during embryogenesis. Wnt ligands regulate axonal extension, growth cone …

Profilin is an abundant actin monomer-binding protein with critical actin regulatory roles in
vivo [1, 2]. However, profilin also influences microtubule dynamics in cells, which may be …

Actin filaments and microtubules are cytoskeletal polymers that participate in many vital cell
functions including division, morphogenesis, phagocytosis, and motility. Despite the …

Although originally identified as G‐actin sequestering proteins, profilins are emerging as
critical regulators of actin dynamics, capable of interacting with multiple acting binding …

The actin containing tropomyosin and troponin decorated thin filaments form one of the
crucial components of the contractile apparatus in muscles. The thin filaments are organized …

Actin and microtubules play essential roles in aberrant cell processes that define and
converge in cancer including: signaling, morphology, motility, and division. Actin and …

Directed outgrowth of axons is fundamental for the establishment of neuronal networks.
Axon outgrowth is guided by growth cones, highly motile structures enriched in filamentous …