Hepatitis B virus (HBV) contributes to hepatocellular carcinoma (HCC) development through
direct and indirect mechanisms. HBV DNA integration into the host genome occurs at early …

Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer-related death. Its
mortality has increased in Western populations, with a minority of patients diagnosed at …

Hepatitis B and C viruses are a global health problem causing acute and chronic infections
that can lead to liver cirrhosis and hepatocellular carcinoma (HCC). These infections are the …

The natural history of chronic hepatitis B virus (HBV) infection and disease is complex and
highly variable. We review the natural history of chronic hepatitis B with emphasis on the …

Hepatocellular carcinoma (HCC) is a frequent malignancy worldwide with a high rate of
metastasis. The hepatitis B and C viruses are considered major etiological factors …

The tumor microenvironment has been largely studied as a dynamic system orchestrated by
inflammatory cells, including cancer cells, stroma as well as the extracellular matrix. It is …

The mechanism underlying persistent hepatitis B virus (HBV) infection remains unclear. We
investigated the role of innate immune responses to persistent HBV infection in 154 HBV …

Ten hepatitis B virus (HBV) genotypes (AJ) and 34 HBV subgenotypes have been identified
so far. HBV genotypes and subgenotypes have distinct geographical distributions, and have …

Liver carcinogenesis is a complex and multi-factorial process, in which both environmental
and genetic features interfere and contribute to malignant transformation. Patients with …

Chronic hepatitis B is the most common cause of hepatocellular carcinoma (HCC) in Asia.
Integration of hepatitis B virus (HBV) genome is likely an early event of carcinogenesis. The …