Growth factors and their respective receptors are key regulators during development and for
homeostasis of the nervous system. In addition, changes in growth factor function …

The Hedgehog morphogen aroused an enormous interest since it was characterized as an
essential signal for ventral patterning of the spinal cord two decades ago. The pathway is …

Progenitors within the ventral telencephalon can generate GABAergic neurons and
oligodendrocytes, but regulation of the neuron-glial switch is poorly understood. We …

Secreted Hedgehog (HH) ligands signal through the canonical receptor Patched (PTCH1).
However, recent studies implicate three additional HH-binding, cell-surface proteins, GAS1 …

The hedgehog (Hh) signaling pathway regulates progenitor cells during embryogenesis and
tumorigenesis in multiple organ systems. We have investigated the activity of this pathway in …

The goal of this project was to develop 3-D biomaterial scaffolds that present cues to direct
the differentiation of embryonic stem (ES) cell-derived neural progenitor cells, seeded inside …

The correct targeting of myelin is essential for nervous system formation and function.
Oligodendrocytes in the CNS myelinate some axons, but not others, and do not myelinate …

During development, the secreted molecule Sonic Hedgehog (Shh) is required for lineage
specification and proliferation of oligodendrocyte progenitors (OLPs), which are the glia cells …

Central nervous system (CNS) development starts from neural stem cells (NSCs) which
ultimately give rise to the three major cell types (neurons, oligodendrocytes and astrocytes) …

Down syndrome (DS), or trisomy 21, is the most prevalent chromosomal anomaly
accounting for cognitive impairment and intellectual disability (ID). Neuropathological …