The brain has almost no energy reserve, but its activity coordinates organismal function, a
burden that requires precise coupling between neurotransmission and energy metabolism …

Excitotoxicity is classically defined as the neuronal damage caused by the excessive
release of glutamate, and subsequent activation of excitatory plasma membrane receptors …

Neurons require large amounts of energy, but whether they can perform glycolysis or require
glycolysis to maintain energy remains unclear. Using metabolomics, we show that human …

Human studies consistently identify bioenergetic maladaptations in brains upon aging and
neurodegenerative disorders of aging (NDAs), such as Alzheimer's disease, Parkinson's …

It has long been recognized that energy metabolism is linked to the production of reactive
oxygen species (ROS) and critical enzymes allied to metabolic pathways can be affected by …

Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive and fatal
neurodegenerative disorder that primarily affects motor neurons. Despite our increased …

Excessive poly (ADP-ribose)(PAR) polymerase-1 (PARP-1) activation kills cells via a cell-
death process designated “parthanatos” in which PAR induces the mitochondrial release …

Neuronal activity is a high‐energy demanding process recruiting all neural cells that adapt
their metabolism to sustain the energy and redox balance of neurons. During …

Background Cancer cells favor the use of less efficient glycolysis rather than mitochondrial
oxidative phosphorylation to metabolize glucose, even in oxygen-rich conditions, a distinct …

The recent identification of the mitochondrial Ca2+ uniporter gene (Mcu/Ccdc109a) has
enabled us to address its role, and that of mitochondrial Ca2+ uptake, in neuronal …