Intrinsic spinal networks, known as central pattern generators (CPGs), control the timing and
pattern of the muscle activity underlying locomotion in mammals. This review discusses new …

The basic motor patterns underlying rhythmic limb movements during locomotion are
generated by neuronal networks located within the spinal cord. These networks are called …

Local neuronal networks that are responsible for walking are poorly characterized in
mammals. Using an innovative approach to identify interneuron inputs onto motorneuron …

Functional MRI (fMRI) imaging of motoneuron activity in the human spinal cord is still in its
infancy, and it will remain difficult to apply to walking. Here we present a viable alternative …

We review here experiments examining the hypothesis that vertebrate spinal motor systems
produce movement through the flexible combination of a small number of units of motor …

The aim of this study was to produce a dynamic model of the spatiotemporal activation of
ensembles of alpha motoneurons (MNs) in the cat lumbosacral spinal cord during the …

Previous studies have shown that a group of ventrally located neurons, designated V2a
interneurons, play a key role in maintaining locomotor rhythmicity and in ensuring …

Despite significant advances in our understanding of pattern generation in invertebrates and
lower vertebrates, there have been barriers to the application of the principles learned to the …

Recent work on the circuits that generate rhythmic movements illustrates the role of
cotransmitter complement in motor pattern selection and demonstrates that many principles …

Left–right alternation depends on activity in commissural interneurons (CINs) that have
axons crossing in the midline. In this study, we investigate the CIN connectivity to local motor …