Infections with protozoan parasites are a major cause of disease and mortality in many
tropical countries of the world. Diseases caused by species of the genera Trypanosoma …

The coupling between electron and proton transfers has a long experimental and theoretical
history in chemistry and biochemistry. To take just one example, the fact that acceptance of …

Rhinacanthone (1) and two 1, 2-pyranonaphthoquinones (2, 3) were synthesized and found
to show very potent cytotoxicity against three cancer cell lines (KB, HeLa and HepG2) with …

Abstract Chagas disease and Human African Trypanosomiasis (HAT) are caused by
Trypanosoma cruzi and T. brucei parasites, respectively. Cruzain (CRZ) and Rhodesain …

This review article summarizes recent applications of electrochemical techniques to redox-
active drug development and mechanistic studies. It includes a general introduction to the …

A series of 2-substituted amino-3-chloro-1, 4-naphthoquinone derivatives (3–12) were
synthesized as anticancer agents and tested against four cancer cell lines including HepG2 …

Naphthoquinones have been extensively studied due to their activity as topoisomerase
inhibitors. These enzymes are critical to DNA replication in cells. In addition …

Catalyst/HypoGen pharmacophore modeling approach and three-dimensional quantitative
structure− activity relationship (3D-QSAR)/comparative molecular similarity indices analysis …

Chagas disease is one of the most important endemic diseases in Latin America, caused by
Trypanosoma cruzi. The drugs used for the treatment of this disease, nifurtimox and …