Prostate cancer has the highest prevalence of any nonskin cancer in the human body, with
similar likelihood of neoplastic foci found within the prostates of men around the world …

The biosynthesis of the zinc finger transcription factor Egr‐1 is stimulated by many
extracellular signaling molecules including hormones, neurotransmitters, growth and …

Intra-tumor heterogeneity is one of the biggest challenges in cancer treatment today. Here
we investigate tissue-wide gene expression heterogeneity throughout a multifocal prostate …

Alteration of the PTEN/PI3K pathway is associated with late-stage and castrate-resistant
prostate cancer (CRPC). However, how PTEN loss is involved in CRPC development is not …

Abstract The Pathological Classification of Prostate Lesions in Genetically Engineered Mice
(GEM) is the result of a directive from the National Cancer Institute Mouse Models of Human …

Heparanase is an endoglycosidase which cleaves heparan sulfate (HS) and hence
participates in degradation and remodeling of the extracellular matrix (ECM). Heparanase is …

Abstract Early growth response-1 (EGR1) is a transcription factor correlated with prostate
cancer (PC) progression in a variety of contexts. For example, EGR1 levels increase in …

Recent studies are reviewed indicating that the transcription factor early growth response-1
(Egr1) is a direct regulator of multiple tumor suppressors including TGFβ1, PTEN, p53, and …

Defects in PTEN, a tumor suppressor, have been found in cancers arising in a variety of
human tissues. To elucidate the tumor-suppressive function of this gene, we have been …

The homeodomain-containing transcription factor NKX3. 1 is a putative prostate tumor
suppressor that is expressed in a largely prostate-specific and androgen-regulated manner …