Clinical trials in Wilms tumor (WT) have resulted in overall survival rates of greater than 90%.
This achievement is especially remarkable because improvements in disease-specific …

Wilms tumour is the most common renal malignancy of childhood. The disease is curable in
the majority of cases, albeit at considerable cost in terms of late treatment-related effects in …

Adult stem cell-derived organoids are three-dimensional epithelial structures that
recapitulate fundamental aspects of their organ of origin. We describe conditions for the long …

PURPOSE Wilms tumor (WT) is associated with (epi) genetic predisposing factors affecting a
growing number of WT predisposing genes and loci, including those causing Beckwith …

MicroRNAs (miRNAs) are important regulators of gene expression, and the dysregulation of
miRNAs is a common feature of several diseases. More miRNAs are identified almost daily …

The development of childhood solid tumours is tied to early developmental processes.
These tumours may be complex and heterogeneous, and elucidating the aberrant …

MicroRNAs (miRNAs) belong to a class of endogenous small noncoding RNAs that regulate
gene expression at the posttranscriptional level, through both translational repression and …

Despite an impressive increase in survival rate over the past decades, there is still a need to
improve the survival of specific subgroups of Wilms tumor (anaplastic, metastatic, and …

Background Wilms tumor (WT) exhibits structural and epigenetic changes at chromosome
11p15, which also cause Beckwith-Wiedemann Syndrome (BWS). Children diagnosed with …

Abstract Introduction Pluripotent stem cells (PSCs) are promising tools for modern
regenerative medicine applications because of their stemness properties, which include …