Free radicals: properties, sources, targets, and their implication in various diseases

A Phaniendra, DB Jestadi, L Periyasamy - Indian journal of clinical …, 2015 - Springer
Free radicals and other oxidants have gained importance in the field of biology due to their
central role in various physiological conditions as well as their implication in a diverse range …

8-oxoguanine and 8-oxodeoxyguanosine Biomarkers of Oxidative DNA Damage: A Review on HPLC–ECD Determination

AM Chiorcea-Paquim - Molecules, 2022 - mdpi.com
Reactive oxygen species (ROS) are continuously produced in living cells due to metabolic
and biochemical reactions and due to exposure to physical, chemical and biological agents …

Antioxidants and human diseases

P Rajendran, N Nandakumar, T Rengarajan… - Clinica chimica acta, 2014 - Elsevier
Oxidative stress plays a pivotal role in the development of human diseases. Reactive
oxygen species (ROS) that includes hydrogen peroxide, hyphochlorus acid, superoxide …

Oxidative stress in cognitive and epigenetic aging: a retrospective glance

A Kandlur, K Satyamoorthy… - Frontiers in molecular …, 2020 - frontiersin.org
Brain aging is the critical and common factor among several neurodegenerative disorders
and dementia. Cellular, biochemical and molecular studies have shown intimate links …

Oxidative stress in the pathogenesis of colorectal cancer: cause or consequence?

M Perše - BioMed research international, 2013 - Wiley Online Library
There is a growing support for the concept that reactive oxygen species, which are known to
be implicated in a range of diseases, may be important progenitors in carcinogenesis …

[HTML][HTML] Mitochondrial oxidative stress, aging and caloric restriction: the protein and methionine connection

R Pamplona, G Barja - Biochimica Et Biophysica Acta (BBA)-Bioenergetics, 2006 - Elsevier
Caloric restriction (CR) decreases aging rate and mitochondrial ROS (MitROS) production
and oxidative stress in rat postmitotic tissues. Low levels of these parameters are also typical …

Oxidative stress in carcinogenesis

JE Klaunig, Z Wang - Current Opinion in Toxicology, 2018 - Elsevier
Carcinogenesis is a multistep process involving both mutation of critical genes and
increased cell proliferation. Over production of oxygen species (ROS) occurs from …

Does measurement of oxidative damage to DNA have clinical significance?

MS Cooke, R Olinski, MD Evans - Clinica Chimica Acta, 2006 - Elsevier
Oxidative damage to DNA is the seemingly inevitable consequence of cellular metabolism.
Furthermore, despite protective mechanisms, cellular levels of damage may increase under …

Oxidative damage to RNA in aging and neurodegenerative disorders

A Nunomura, PI Moreira, RJ Castellani, H Lee… - Neurotoxicity …, 2012 - Springer
An age-associated increase in oxidative damage to nucleic acids, predominantly to RNA,
has been recently demonstrated in neurons of human and rodent brains, which may play a …

The genome as a life-history character: why rate of molecular evolution varies between mammal species

L Bromham - … Transactions of the Royal Society B …, 2011 - royalsocietypublishing.org
DNA sequences evolve at different rates in different species. This rate variation has been
most closely examined in mammals, revealing a large number of characteristics that can …