Abstracts Genomic DNA is modified in a postreplicative manner and several modifications,
the enzymes responsible for their deposition as well as proteins that read these …

Encephalitogenic T cells are heavily implicated in the pathogenesis of multiple sclerosis
(MS), an autoimmune demyelinating disease of the central nervous system. Their stimulation …

Epigenetic pathways are involved in a wide range of diseases, including cancer and
neurological disorders. Specifically, histone modifying and reading processes are the most …

DFT calculations are employed to quantify the influence of the presence, number, nature,
and position of posttranscriptional methylation on stacking strength of RNA bases. We carry …

Purpose DNA methylation is a well-characterized epigenetic repressor of mRNA
transcription in many plant and vertebrate systems. However, the mechanism of this …

There are four known epigenetic cytosine modifications in mammals: methylation (5mC),
hydroxymethylation (5hmC), formylation (5fC) and carboxylation (5caC). The biological …

We introduce the concept of Convertible and Constrained Nucleic Acids (C2NAs). By means
of the synthesis of a stereocontrolled N-propargyl dioxo-1, 3, 2-oxaza-phosphorinane as an …

Objective: This article aims to address the need to rethink the classification of mental illness
and to draw attention to the current use of quantum biology and its likely future use in …

Purpose DNA methylation is a well characterized epigenetic repressor of mRNA
transcription in many plant and vertebrate systems. However, the mechanism of this …

Biological molecules often undergo large structural changes to perform their function.
Computational methods can provide a fine-grained description at the atomistic scale …