The surprising discovery that the diatomic gas nitric oxide (NO) is generated by mammalian
cells and serves to regulate a multitude of physiological processes has continued to …

Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

In heart failure, alterations of Na+ and Ca2+ handling, energetic deficit, and oxidative stress
in cardiac myocytes are important pathophysiological hallmarks. Mitochondria are central to …

Dysfunction of the endothelial lining of lesion-prone areas of the arterial vasculature is an
important contributor to the pathobiology of atherosclerotic cardiovascular disease …

Nitric oxide (NO) is a key signalling molecule in the cardiovascular, immune and central
nervous systems, and crucial steps in the regulation of NO bioavailability in health and …

Reactive oxygen, nitrogen, and sulfur species, referred to as ROS, RNS, and RSS,
respectively, are produced during normal cell function and in response to various stimuli. An …

Acute myocardial infarction (MI) is the leading cause of death worldwide. Exogenous
delivery of nitric oxide (NO) to the infarcted myocardium has proven to be an effective …

Nitric oxide (NO) is a key player in both the development and suppression of tumourigenesis
depending on the source and concentration of NO. In this review, we discuss the …

Nitric oxide (NO) is a pleiotropic janus-faced molecule synthesized by nitric oxide synthases
(NOS) which plays a critical role in a number of physiological and pathological processes in …

Significance: Protein S-nitrosylation, the oxidative modification of cysteine by nitric oxide
(NO) to form protein S-nitrosothiols (SNOs), mediates redox-based signaling that conveys, in …