Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …

Nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3
(NLRP3) is an intracellular innate immune receptor that recognizes a diverse range of …

The innate immune system includes several classes of pattern recognition receptors (PRRs),
including membrane-bound Toll-like receptors (TLRs) and nucleotide-binding …

Background The NLR family, pyrin domain containing 3 (NLRP 3) inflammasome is an
interleukin (IL)‐1β and IL‐18 cytokine processing complex that is activated in inflammatory …

Cardiovascular disease is a major cause of death worldwide. Inflammasome infiltration has
been identified to play a central role in the pathological progression of certain …

The role of inflammation in neurological disorders is increasingly recognised. Inflammatory
processes are associated with the aetiology and clinical progression of migraine, psychiatric …

Objectives Twenty-eight genetic loci are associated with serum urate levels in Europeans.
Evidence for association with gout at most loci is absent, equivocal or not replicated. Our aim …

Aortic diseases comprise aneurysms, dissections, and several other pathologies. In general,
aging is associated with a slow but progressive dilation of the aorta, along with increased …

Toll-like receptors (TLRs) are a class of receptors of the innate immune system which detect
pathogen-associated and danger-associated molecular patterns in order to initiate an …

Objective—Increasing evidence suggests that contractile dysfunction in smooth muscle cells
(SMCs) plays a critical role in aortic biomechanical dysfunction and aortic aneurysm and …