Covering: 2000 to 2018 The antimicrobial activity of many of their natural products has
brought prominence to the Streptomycetaceae, a family of Gram-positive bacteria that …

Nitrogen is an essential element required for bacterial growth. It serves as a building block
for the biosynthesis of macromolecules and provides precursors for secondary metabolites …

Abstract Background The Streptomyces albus J1074 strain is one of the most widely used
chassis for the heterologous production of bioactive natural products. The fast growth and an …

Streptogramins are potent drugs against numerous highly resistant pathogens and therefore
are used as antibiotics of last-resort human therapy. They consist of a mixture of two different …

The two‐component system AfsQ1/Q2 of S treptomyces coelicolor was identified in our
previous work as a pleiotropic regulator for antibiotic biosynthesis and morphological …

Background GlnR is an atypical response regulator found in actinomycetes that modulates
the transcription of genes in response to changes in nitrogen availability. We applied a …

Bacteria of the Streptomyces genus constitute an authentic biotech gold mine thanks to their
ability to produce a myriad of compounds and enzymes of great interest at various clinical …

Soil dwelling Streptomyces species are faced with large variations in carbon or nitrogen
sources, phosphate, oxygen, iron, sulfur, and other nutrients. These drastic changes in key …

Streptomyces species are a wide and diverse source of many therapeutic agents
(antimicrobials, antineoplastic and antioxidants, to name a few) and represent an important …

Bacteria in the genus Streptomyces are soil-dwelling oligotrophs and important producers of
secondary metabolites. Previously, we showed that global messenger RNA expression was …