Gastric cancer treatment: recent progress and future perspectives

WL Guan, Y He, RH Xu - Journal of hematology & oncology, 2023 - Springer
Gastric cancer (GC) is one of the most common malignancies worldwide. Most patients are
diagnosed at advanced stages due to the subtle symptoms of earlier disease and the low …

Rational combinations of targeted cancer therapies: background, advances and challenges

H Jin, L Wang, R Bernards - Nature Reviews Drug Discovery, 2023 - nature.com
Over the past two decades, elucidation of the genetic defects that underlie cancer has
resulted in a plethora of novel targeted cancer drugs. Although these agents can initially be …

Esophageal and esophagogastric junction cancers, version 2.2023, NCCN clinical practice guidelines in oncology

JA Ajani, TA D'Amico, DJ Bentrem, D Cooke… - Journal of the National …, 2023 - jnccn.org
Cancers originating in the esophagus or esophagogastric junction constitute a major global
health problem. Esophageal cancers are histologically classified as squamous cell …

Mechanisms driving the immunoregulatory function of cancer cells

A van Weverwijk, KE de Visser - Nature Reviews Cancer, 2023 - nature.com
Tumours display an astonishing variation in the spatial distribution, composition and
activation state of immune cells, which impacts their progression and response to …

Pembrolizumab plus trastuzumab and chemotherapy for HER2-positive gastric or gastro-oesophageal junction adenocarcinoma: interim analyses from the phase 3 …

YY Janjigian, A Kawazoe, Y Bai, J Xu, S Lonardi… - The Lancet, 2023 - thelancet.com
Background Evidence for the efficacy of combined PD-1 and HER2 blockade with
chemotherapy on progression-free and overall survival in HER2-positive gastro …

Tumor cell plasticity in targeted therapy-induced resistance: mechanisms and new strategies

ZD Shi, K Pang, ZX Wu, Y Dong, L Hao… - … and Targeted Therapy, 2023 - nature.com
Despite the success of targeted therapies in cancer treatment, therapy-induced resistance
remains a major obstacle to a complete cure. Tumor cells evade treatments and relapse via …

[HTML][HTML] Korean practice guidelines for gastric cancer 2022: an evidence-based, multidisciplinary approach

TH Kim, IH Kim, SJ Kang, M Choi, BH Kim… - Journal of gastric …, 2023 - ncbi.nlm.nih.gov
Gastric cancer is one of the most common cancers in Korea and the world. Since 2004, this
is the 4th gastric cancer guideline published in Korea which is the revised version of …

Signaling pathways and therapeutic interventions in gastric cancer

ZN Lei, QX Teng, Q Tian, W Chen, Y Xie… - Signal transduction and …, 2022 - nature.com
Gastric cancer (GC) ranks fifth in global cancer diagnosis and fourth in cancer-related death.
Despite tremendous progress in diagnosis and therapeutic strategies and significant …

[HTML][HTML] Updates on global epidemiology, risk and prognostic factors of gastric cancer

WJ Yang, HP Zhao, Y Yu, JH Wang, L Guo… - World Journal of …, 2023 - ncbi.nlm.nih.gov
Gastric cancer (GC) is defined as the primary epithelial malignancy derived from the
stomach, and it is a complicated and heterogeneous disease with multiple risk factors …

Immunotherapy and targeted therapy for advanced gastroesophageal cancer: ASCO guideline

MA Shah, EB Kennedy, AE Alarcon-Rozas… - Journal of Clinical …, 2023 - ascopubs.org
PURPOSE To develop recommendations involving targeted therapies for patients with
advanced gastroesophageal cancer. METHODS The American Society of Clinical Oncology …