Evading persistent drug resistance in cancer and bacteria is quintessential to restore health
in humans, and impels intervention strategies. A distinct property of the cancer phenotype is …

Bacteria are the most diverse and numerous organisms on the planet, inhabiting
environments from the deep subsurface to particles in clouds. Across this range of …

Understanding the mechanisms of antimicrobial resistance (AMR) will help launch a counter-
offensive against human pathogens that threaten our ability to effectively treat common …

The intracellular production of reactive oxygen species (ROS), composed of oxygen-
reduced molecules, is important not only because of their lethal effects on microorganisms …

The ability of Mycobacterium tuberculosis to resist intraphagosomal stresses, such as
oxygen radicals and low pH, is critical for its persistence. Here, we show that a cytoplasmic …

Mycobacterium tuberculosis (Mtb) has complex and dynamic interactions with the human
host, and subpopulations of Mtb that emerge during infection can influence disease …

Early diagnosis of tuberculosis (TB), followed by effective treatment, is the cornerstone of
global TB control efforts. An estimated 3 million cases of TB remain undetected each year …

Reactive oxygen species (ROS) are transient, highly reactive intermediates or byproducts
produced during oxygen metabolism. However, when innate mechanisms are unable to …

Host redox dependent physiological responses play crucial roles in the determination of
mycobacterial infection process. Mtb explores oxygen rich lung microenvironments to initiate …

Abstract Significance: Mycothiol (MSH, AcCys-GlcN-Ins) is the main low-molecular weight
(LMW) thiol of most Actinomycetes, including the human pathogen Mycobacterium …