The JAK/STAT3 signaling pathway plays an essential role in various types of cancers.
Activation of this pathway leads to increased tumorigenic and metastatic ability, the transition …

The transcription factor NF-κB is a critical regulator of immune and inflammatory responses.
In mammals, the NF-κB/Rel family comprises five members: p50, p52, p65 (Rel-A), c-Rel …

The nuclear factor kappa B (NFκB) family of transcription factors is a key regulator of immune
development, immune responses, inflammation, and cancer. The NFκB signaling system …

The NF-κB transcription factor was discovered 30 years ago and has since emerged as the
master regulator of inflammation and immune homeostasis. It achieves this status by means …

Aging and various age-related diseases are associated with reductions in melatonin
secretion, proinflammatory changes in the immune system, a deteriorating circadian system …

The NF-κB transcription factor is the master regulator of the inflammatory response and is
essential for the homeostasis of the immune system. NF-κB regulates the transcription of …

Abstract Toll-like receptor 3 (TLR3) is a member of the TLR family, mediating the
transcriptional induction of type I interferons (IFNs), proinflammatory cytokines, and …

The NF-κB family of inducible transcription factors is activated in response to a variety of
stimuli. Amongst the best-characterized inducers of NF-κB are members of the TNF family of …

The peptidyl-prolyl isomerase, Pin1, is exploited in cancer to activate oncogenes and
inactivate tumor suppressors. However, despite considerable efforts, Pin1 has remained an …

Nuclear factor-κB (NF-κB) consists of a family of transcription factors that play critical roles in
inflammation, immunity, cell proliferation, differentiation, and survival. Inducible NF-κB …