Chemists, like artists, are able to construct new threedimensional objects, molecules and
materials that exist only in the mind of a person. I became interested in creating novel …

DNA has for many years been the traditional target for chemotherapeutic intervention1 in
human cancers, especially for those where high proliferation rates of some tumour cell types …

Oligonucleotides are designed to target RNA using base pairing rules, but they can be
hampered by poor cellular delivery and nonspecific stimulation of the immune system. Small …

The development of small molecules that target RNA is challenging yet, if successful, could
advance the development of chemical probes to study RNA function or precision …

Understanding the thermodynamics of drug binding to DNA is of both practical and
fundamental interest. The practical interest lies in the contribution that thermodynamics can …

The design of synthetic ligands that read the information stored in the DNA double helix has
been a long-standing goal at the interface of chemistry and biology,,,,. Cell-permeable small …

Significant progress has been made over the past few years in studies of drug—DNA
interactions. Structure-based design strategies have yielded new DNA-binding agents with …

Small molecules that target specific DNA sequences offer a potentially general approach for
the regulation of gene expression. Pyrrole–imidazole polyamides represent the only class of …

Background: Cell-permeable small molecules that target predetermined DNA sequences
with high affinity and specificity have the potential to control gene expression. A binary code …

Selective placement of an aliphatic β-alanine (β) residue paired side-by-side with either a
pyrrole (Py) or imidazole (Im) aromatic amino acid is found to compensate for sequence …