Several epidemiological studies show an inverse association between cancer and
Alzheimer's disease (AD). It is debated whether this association is the consequence of …

Amyloid precursor protein (APP) and its family members amyloid precursor-like protein 1
(APLP1) and amyloid precursor-like protein 2 (APLP2) are type 1 transmembrane …

Metastasis is the leading cause of cancer-related death in humans. It is a complex multistep
process during which individual tumour cells spread primarily through the circulatory system …

Tumor cells secrete not only a variety of soluble factors, but also extracellular vesicles that
are known to support the establishment of a favorable tumor niche by influencing the …

p53 mutants can form amyloid-like structures that accumulate in cells. p53 reactivation with
induction of massive apoptosis-1 (PRIMA-1) and its primary active metabolite, 2-methylene …

Amyloid precursor protein (APP) is a type 1 transmembrane glycoprotein, and its homologs
amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) are …

Background Amyloid-β precursor protein (APP) is a highly conserved single transmembrane
protein that has been linked to Alzheimer disease. Recently, the increased expression of …

Background Pin1 is an intracellular signaling molecule which plays a critical but opposite
role in the pathogenesis of Alzheimer's disease (AD) and many human cancers. Scope of …

To verify whether amyloid precursor protein (APP) affects the migration and invasion of
breast cancer cell lines, and to understand its underlying mechanisms, epithelial …

BACE1 and BACE2 belong to a class of proteases called β-secretases involved in
ectodomain shedding of different transmembrane substrates. These enzymes have been …