Mesoscale clusters in the crystallisation of organic molecules

H Barua, M Svärd, ÅC Rasmuson… - Angewandte Chemie …, 2024 - Wiley Online Library
The early stages of the molecular self‐assembly pathway leading to crystal nucleation have
a significant influence on the properties and purity of organic materials. This mini review …

Conceptual validation of stochastic and deterministic methods to estimate crystal nucleation rates

LT Deck, M Mazzotti - Crystal Growth & Design, 2022 - ACS Publications
This work presents a generalized framework to assess the accuracy of methods to estimate
primary and secondary nucleation rates from experimental data. The crystallization process …

The interplay between nucleation and patterning during shear-induced crystallization from solution in a parallel plate geometry

C Devos, A Vananroye, R Cardinaels, C Xiouras… - Soft Matter, 2023 - pubs.rsc.org
Cooling crystallization of small organic molecules from solution is an important operation for
the separation and purification of drug products. In this research, shear-induced nucleation …

Solution-Mediated Phase Transformation Processes of Amorphous Iohexol: Mechanisms and Its Applications

S Shen, X Wang, C Dong, W Zhao… - Crystal Growth & …, 2025 - ACS Publications
Iohexol demonstrates a tendency to form particles in its amorphous state during the
crystallization process. To obtain crystalline iohexol particles, the phase transformation of …

The influence of solute concentration and filtration on mesoscale clusters of flufenamic acid, a typical pharmaceutical compound, in ethanol

H Barua, J Cookman, M Svärd, Å Rasmuson… - Journal of Colloid and …, 2025 - Elsevier
Hypothesis It is hypothesised in this work that mesoscale clusters will be present in both
undersaturated and supersaturated solutions of organic pharmaceutical molecules. These …

Characterizing Mesoscopic Species Present in Solution and Modeling Their Roles in Crystallization Processes

B Ahn - 2022 - research-collection.ethz.ch
Crystallization usually occurs in two steps: nucleation (appearance of a crystalline phase)
and growth (increase in the size of crystals). In both steps, solute molecules arrange into a …