Oligodendrocytes generate multiple layers of myelin membrane around axons of the central
nervous system to enable fast and efficient nerve conduction. Until recently, saltatory nerve …

The biology of the human brain, and in particular the dynamic interactions between the
numerous cell types and regions of the central nervous system, has been difficult to study …

Investigating human oligodendrogenesis and the interaction of oligodendrocytes with
neurons and astrocytes would accelerate our understanding of the mechanisms underlying …

Cerebral organoids provide an accessible system for investigations of cellular composition,
interactions, and organization but have lacked oligodendrocytes, the myelinating glia of the …

Leukodystrophies comprise a large group of rare genetic disorders primarily affecting CNS
white matter. Historically, the diagnostic process was slow and patient prognosis regarded …

RNA polymerase (Pol) III transcribes small untranslated RNAs such as 5S ribosomal RNA,
transfer RNAs, and U6 small nuclear RNA. Because of the functions of these RNAs, Pol III …

Diseases and aging-associated alterations of the nervous system often show sex-specific
characteristics. Glial cells play a major role in the endogenous homeostatic response of …

Human stem cell derived brain organoids are increasingly gaining attention as an ideal
model system for investigating neurological diseases, particularly those that involve …

Developing efficient models for neurological diseases enables us to uncover disease
mechanisms and develop therapeutic strategies to treat them. Discovery of reprogramming …

Pelizaeus-Merzbacher disease (PMD) is an X-linked leukodystrophy caused by mutations in
Proteolipid Protein 1 (PLP1), encoding a major myelin protein, resulting in profound …