The first mammalian Wnt to be discovered, Wnt-1, was found to be essential for the
development of a large part of the mouse brain over 25 years ago. We have since learned …

Spinal cord injury (SCI) causes myelopathy, damage to white matter, and myelinated fiber
tracts that carry sensation and motor signals to and from the brain. The gray matter damage …

The cardinal motor symptoms of Parkinson's disease (PD) are caused by the vulnerability to
dysfunction and degeneration of ventral midbrain (VM) dopaminergic (DA) neurons. A major …

BACKGROUND: Although the transplantation of mesenchymal stem cells (MSCs) after
spinal cord injury (SCI) has shown promising results in animals, less is known about the …

Background Directed differentiation of human induced pluripotent stem cells (hiPSC) into
functional, region-specific neural cells is a key step to realizing their therapeutic promise to …

Human embryonic stem cells (hESCs) hold great promise for regenerative medicine and
transplantation therapy due to their self-renewal and pluripotent properties. We report that …

Efficient derivation of neural cells from human embryonic stem cells (hESCs) remains an
unmet need for the treatment of neurological disorders. The limiting factors for current …

Recent breakthroughs in stem cell biology, especially the development of induced
pluripotent stem cell technique, have generated tremendous enthusiasm and efforts to …

Spinal cord injury (SCI) usually results in long lasting locomotor and sensory neuron
degeneration below the injury. Astrocytes normally play a decisive role in mechanical and …

Since last few years, an impressive amount of data has been generated regarding the basic
in vitro and in vivo biology of neural stem cells (NSCs) and there is much far hope for the …